Recent advances in synthetic strategies and SAR of thiazolidin-4-one containing molecules in cancer therapeutics

• Published in: Cancer and metastasis reviews Vol. 42; no. 3; pp. 847 - 889
• Main Authors: Sharma, Archana, Sharma, Diksha, Saini, Neha, Sharma, Sunil V., Thakur, Vijay Kumar, Goyal, Ramesh K., Sharma, Prabodh Chander
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2023; Springer; Springer Nature B.V
• Subjects: Antitumor activity; Antitumor agents; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Chemotherapy; Development and progression; Enzyme inhibitors; Enzymes; Heterocyclic compounds; Oncology; Thiazolidin-4-one; Anti-proliferative; Anti-tumor; Synthesis; Cell lines; Anticancer; Cytotoxic
• ISSN: 0167-7659; 1573-7233; 1573-7233
• DOI: 10.1007/s10555-023-10106-1

Cancer is one of the life-threatening diseases accountable for millions of demises globally. The inadequate effectiveness of the existing chemotherapy and its harmful effects has resulted in the necessity of developing innovative anticancer agents. Thiazolidin-4-one scaffold is among the most important chemical skeletons that illustrate anticancer activity. Thiazolidin-4-one derivatives have been the subject of extensive research and current scientific literature reveals that these compounds have shown significant anticancer activities. This manuscript is an earnest attempt to review novel thiazolidin-4-one derivatives demonstrating considerable potential as anticancer agents along with a brief discussion of medicinal chemistry-related aspects of these compounds and structural activity relationship studies in order to develop possible multi-target enzyme inhibitors. Most recently, various synthetic strategies have been developed by researchers to get various thiazolidin-4-one derivatives. In this review, the authors highlight the various synthetic, green, and nanomaterial-based synthesis routes of thiazolidin-4-ones as well as their role in anticancer activity by inhibition of various enzymes and cell lines. The detailed description of the existing modern standards in the field presented in this article may be interesting and beneficial to the scientists for further exploration of these heterocyclic compounds as possible anticancer agents.