Cell and Animal Models for SARS-CoV-2 Research

During the last two years following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, development of potent antiviral drugs and vaccines has been a global health priority. In this context, the understanding of virus pathophysiology, the identification of associated therapeut...

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Bibliographic Details
Published inViruses Vol. 14; no. 7; p. 1507
Main Authors Bestion, Eloïne, Halfon, Philippe, Mezouar, Soraya, Mège, Jean-Louis
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 09.07.2022
MDPI
Subjects
animal model
Animal models
Animals
Antiviral agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Antiviral drugs
Biological models
Cell culture
cell model
Clinical trials
Coronaviruses
COVID-19
Disease transmission
drug
Drug development
evolution
human diseases
Humans
Infections
Medical research
Medicine, Experimental
Models, Animal
pandemic
Pandemics
Pandemics - prevention & control
Pathophysiology
Public health
Review
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Therapeutic targets
therapeutics
viruses
France
COVID-19
SARS-CoV-2
animal model
cell model
drug
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ISSN1999-4915
1999-4915
DOI10.3390/v14071507

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Summary:During the last two years following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, development of potent antiviral drugs and vaccines has been a global health priority. In this context, the understanding of virus pathophysiology, the identification of associated therapeutic targets, and the screening of potential effective compounds have been indispensable advancements. It was therefore of primary importance to develop experimental models that recapitulate the aspects of the human disease in the best way possible. This article reviews the information concerning available SARS-CoV-2 preclinical models during that time, including cell-based approaches and animal models. We discuss their evolution, their advantages, and drawbacks, as well as their relevance to drug effectiveness evaluation.
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These authors contributed equally to this work.
ISSN:1999-4915
1999-4915
DOI:10.3390/v14071507