Gestational trophoblastic neoplasia: A 6 year retrospective study

• Published in: South Asian Journal of Cancer Vol. 3; no. 1; pp. 033 - 037
• Main Authors: Shrivastava, Sushruta, Kataki, Amal Chandra, Barmon, Debabrata, Deka, Pankaj, Bhuyan, Chidananda, Bhargav, Saikia J.
• Format: Journal Article
• Language: English
• Published: A-12, 2nd Floor, Sector 2, Noida-201301 UP, India Thieme Medical and Scientific Publishers Pvt. Ltd 01.01.2014; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd
• Subjects: Actinomycin-D; Cancer; Chemotherapy; choriocarcinoma; Drug therapy; EMACO regimen; FEMALE REPRODUCTIVE TRACT TUMORS : Original Article; FEMALE REPRODUCTIVE TRACT TUMORS: Original; Genetic disorders; gestational trophoblastic neoplasia; Methotrexate; Oncology, Experimental; Physiological aspects; Pakistan; Actinomycin-D; EMACO regimen; Methotrexate; chemotherapy; gestational trophoblastic neoplasia; choriocarcinoma
• ISSN: 2278-330X; 2278-4306
• DOI: 10.4103/2278-330X.126516

Abstract Aims and Objectives: To study the clinical presentations of gestational trophoblastic neoplasia and its response to chemotherapy. Materials and Methods: This is a retrospective study of 28 women of gestational trophoblastic neoplasia evaluated over a period of 6 years from January 2004 to December 2009. Patients were evaluated on the basis of their age, number of deliveries, history of abortion or molar pregnancy, and the treatment received. All patients were scored on the basis of WHO scoring system. Patients with low risk (score </=6) received single agent chemotherapy with methotrexate or actinomycin D. Patients with high risk (score >/=7) received multiple agent chemotherapy with EMACO regimen. After completion of chemotherapy patients were followed for a minimum of 2 years. The response to treatment was evaluated during follow-up by clinical examination, beta hCG levels and imaging as and when required. Results: Out of 28 women only 27 could be evaluated, because 1 patient was lost to follow-up. Out of 27 patients, 18 patients (66.67%) achieved complete remission with the first-line chemotherapy and additional 25.92% (7/27) achieved complete remission with second line chemotherapy resulting in complete remission of 92.5% (25/27). Conclusion: Gestational trophoblastic neoplasia is curable if patient is properly evaluated and scored. It shows good response to chemotherapy.