New virus of the family Flaviviridae detected in lumpfish (Cyclopterus lumpus)

In this study, we determined the complete coding sequence of a putative new member of the family Flaviviridae , named “Cyclopterus lumpus virus” (CLuV), which is associated with a serious disease in lumpfish ( Cyclopterus lumpus ). The virus was present in all tissues tested, but pathology was prima...

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Published inArchives of virology Vol. 163; no. 3; pp. 679 - 685
Main Authors Skoge, Renate Hvidsten, Brattespe, Jarle, Økland, Arnfinn Lodden, Plarre, Heidrun, Nylund, Are
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 01.03.2018
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Brief Report
Chiroptera
Cyclopterus lumpus
Cylopterus lumpus
Flaviviridae
Infectious Diseases
kidneys
Liver
Medical Microbiology
polyproteins
Virology
viruses
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Summary:In this study, we determined the complete coding sequence of a putative new member of the family Flaviviridae , named “Cyclopterus lumpus virus” (CLuV), which is associated with a serious disease in lumpfish ( Cyclopterus lumpus ). The virus was present in all tissues tested, but pathology was primarily observed in the liver and kidneys. CLuV shows low but distinct similarity to the unassigned Tamana bat virus (TABV). Unlike other known members of the family Flaviviridae , translation of the entire CLuV polyprotein is dependent on a − 1 ribosomal frameshift in the NS2A region.
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Handling Editor: Chan-Shing Lin.
ISSN:0304-8608
1432-8798
1432-8798
DOI:10.1007/s00705-017-3643-3