TET proteins in cancer: Current ‘state of the art’

Highlights • Enzymes involved in DNA demethylation-TET play role in cell differentiation and carcinogenesis. • Level of TETs and their products (oxidized 5-methylcytosines) is altered in many malignances. • Increasing information is available regarding regulation of TET expression/activity in cancer...

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Bibliographic Details
Published inCritical reviews in oncology/hematology Vol. 96; no. 3; pp. 425 - 436
Main Authors Rawłuszko-Wieczorek, Agnieszka Anna, Siera, Agnieszka, Jagodziński, Paweł Piotr
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ireland Ltd 01.12.2015
Subjects
5-hmC
Cancer
DNA Methylation
Hematology, Oncology and Palliative Medicine
Humans
Mixed Function Oxygenases - genetics
Mixed Function Oxygenases - metabolism
Neoplasms - physiopathology
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - metabolism
TET
DNA methylation
TET
5-hmC
Cancer
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Summary:Highlights • Enzymes involved in DNA demethylation-TET play role in cell differentiation and carcinogenesis. • Level of TETs and their products (oxidized 5-methylcytosines) is altered in many malignances. • Increasing information is available regarding regulation of TET expression/activity in cancer. • Readers of 5-mC derivatives need to be identified to estimate its role in cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2015.07.008