Foxo in the immune system

• Published in: Oncogene Vol. 27; no. 16; pp. 2337 - 2344
• Main Author: Peng, S L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.04.2008; Nature Publishing Group
• Subjects: Animals; Apoptosis; Arthritis; Care and treatment; Cell Biology; Cellular biology; DNA binding proteins; Forkhead protein; Forkhead Transcription Factors - physiology; Genetic aspects; Homeostasis; Human Genetics; Humans; Immune system; Immune System - physiology; Inflammation; Inflammatory diseases; Internal Medicine; Leukocytes (neutrophilic); Lymphocytes B; Lymphocytes T; Medicine; Medicine & Public Health; Oncology; Physiological aspects; Properties; Proteins; review; Systemic lupus erythematosus; Therapeutic targets; Transcription factors; United States; B cells; autoimmunity; arthritis; T cells; transcription factors; lupus

In addition to their key roles in cellular survival, death, proliferation and metabolism, the Foxo subfamily of forkhead (Fox) transcription factors play critical roles in the homeostasis of immune-relevant cells, including T cells, B cells, neutrophils and other non-lymphoid lineages that modulate...