Foxo in the immune system

In addition to their key roles in cellular survival, death, proliferation and metabolism, the Foxo subfamily of forkhead (Fox) transcription factors play critical roles in the homeostasis of immune-relevant cells, including T cells, B cells, neutrophils and other non-lymphoid lineages that modulate...

Full description

Saved in:
Bibliographic Details
Published inOncogene Vol. 27; no. 16; pp. 2337 - 2344
Main Author Peng, S L
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 07.04.2008
Nature Publishing Group
Subjects
Animals
Apoptosis
Arthritis
Care and treatment
Cell Biology
Cellular biology
DNA binding proteins
Forkhead protein
Forkhead Transcription Factors - physiology
Genetic aspects
Homeostasis
Human Genetics
Humans
Immune system
Immune System - physiology
Inflammation
Inflammatory diseases
Internal Medicine
Leukocytes (neutrophilic)
Lymphocytes B
Lymphocytes T
Medicine
Medicine & Public Health
Oncology
Physiological aspects
Properties
Proteins
review
Systemic lupus erythematosus
Therapeutic targets
Transcription factors
United States
B cells
autoimmunity
arthritis
T cells
transcription factors
lupus
Online AccessGet full text

Cover

More Information
Summary:In addition to their key roles in cellular survival, death, proliferation and metabolism, the Foxo subfamily of forkhead (Fox) transcription factors play critical roles in the homeostasis of immune-relevant cells, including T cells, B cells, neutrophils and other non-lymphoid lineages that modulate inflammation in disease states such as inflammatory arthritis and systemic lupus erythematosus. This review summarizes such current and expanding knowledge of the Foxo family members in immunity, and their potential as therapeutic targets in inflammatory disease.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0950-9232
1476-5594
DOI:10.1038/onc.2008.26