Autophagy in the Cellular Energetic Balance

Autophagy mediates the degradation of cellular components in lysosomes, assuring removal of altered or dysfunctional proteins and organelles. Autophagy is not only activated in response to cellular damage; in fact, one of its strongest and better-characterized stimuli is starvation. Activation of au...

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Published inCell metabolism Vol. 13; no. 5; pp. 495 - 504
Main Authors Singh, Rajat, Cuervo, Ana Maria
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 04.05.2011
Subjects
Animals
Autophagy
Cell Membrane - metabolism
Energy Metabolism
Humans
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Summary:Autophagy mediates the degradation of cellular components in lysosomes, assuring removal of altered or dysfunctional proteins and organelles. Autophagy is not only activated in response to cellular damage; in fact, one of its strongest and better-characterized stimuli is starvation. Activation of autophagy when nutrients are scarce allows cells to reutilize their own constituents for energy. Besides protein breakdown, autophagy also contributes to the mobilization of diverse cellular energy stores. This recently discovered interplay between autophagy and lipid and carbohydrate metabolism reveals the existence of a dynamic feedback between autophagy and cellular energy balance.
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ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2011.04.004