Microplastics: A Matter of the Heart (and Vascular System)

• Published in: Biomedicines Vol. 11; no. 2; p. 264
• Main Authors: Persiani, Elisa, Cecchettini, Antonella, Ceccherini, Elisa, Gisone, Ilaria, Morales, Maria Aurora, Vozzi, Federico
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.01.2023; MDPI
• Subjects: Angiogenesis; Aquatic organisms; Cardiomyocytes; Cardiotoxicity; Cardiovascular diseases; Cardiovascular system; Chemical contaminants; Circulatory system; contaminants; Contamination; Cytotoxicity; Edema; Endothelium; environmental exposure; Fibrosis; Fish; Fish as food; Fishes; Food chains; Genotoxicity; Gills; Health aspects; Heart; Heart rate; Heavy metals; Immunocompetence; Immunology; Inflammation; Italy; microplastics; nanoplastics; Oxidative stress; Physiological aspects; Plasma proteins; Plastic debris; Plastic pollution; Pollutants; Protein transport; Review; Risk assessment; Risk factors; Thrombosis; Vascular system; Water pollution; Italy; contaminants; cardiovascular system; microplastics; nanoplastics; environmental exposure; heart
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines11020264

Plastic use dramatically increased over the past few years. Besides obvious benefits, the consequent plastic waste and mismanagement in disposal have caused ecological problems. Plastic abandoned in the environment is prone to segregation, leading to the generation of microplastics (MPs) and nanoplastics (NPs), which can reach aquatic and terrestrial organisms. MPs/NPs in water can access fish's bodies through the gills, triggering an inflammatory response in loco. Furthermore, from the gills, plastic fragments can be transported within the circulatory system altering blood biochemical parameters and hormone levels and leading to compromised immunocompetence and angiogenesis. In addition, it was also possible to observe an unbalanced ROS production, damage in vascular structure, and enhanced thrombosis. MPs/NPs led to cardiotoxicity, pericardial oedema, and impaired heart rate in fish cardiac tissue. MPs/NPs effects on aquatic organisms pose serious health hazards and ecological consequences because they constitute the food chain for humans. Once present in the mammalian body, plastic particles can interact with circulating cells, eliciting an inflammatory response, with genotoxicity and cytotoxicity of immune cells, enhanced haemolysis, and endothelium adhesion. The interaction of MPs/NPs with plasma proteins allows their transport to distant organs, including the heart. As a consequence of plastic fragment internalisation into cardiomyocytes, oxidative stress was increased, and metabolic parameters were altered. In this scenario, myocardial damage, fibrosis and impaired electrophysiological values were observed. In summary, MPs/NPs are an environmental stressor for cardiac function in living organisms, and a risk assessment of their influence on the cardiovascular system certainly merits further analysis.