ABNORMAL POLYAMINE METABOLISM IN HYPERTENSIVE CARDIAC HYPERTROPHY

• Published in: JAPANESE CIRCULATION JOURNAL Vol. 52; no. 10; pp. 1209 - 1215
• Main Authors: SHIMIZU, MITSUYUKI, MASUDA, IZURU, AIHARA, KAZUO, NAKANO, TOMOKO, OGAWA, KAZUHIKO, MIZOKAMI, TSUNEO, IRIMAJIRI, OSAMU, TANIGUCHI, IKUO, OZASA, HARUKI, KAGEYAMA, SHIGERU, HAYASHI, SHIN-ICHI, ISOGAI, YUKIHIDE
• Format: Journal Article
• Language: English
• Published: Kyoto The Japanese Circulation Society 1988; Japanese Circulation Society
• Subjects: Animals; Anti-hypertensive agents; Antihypertensive agents; Antihypertensive Agents - administration & dosage; Biogenic Polyamines - metabolism; Biological and medical sciences; Cardiomegaly; Cardiomegaly - enzymology; Cardiomegaly - metabolism; Cardiomegaly - physiopathology; Cardiovascular system; Circadian Rhythm; Heart - physiopathology; Hypertension - enzymology; Hypertension - metabolism; Hypertension - physiopathology; Medical sciences; Myocardium - metabolism; Organ Size; Ornithine Decarboxylase - metabolism; Pharmacology. Drug treatments; Polyamine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity; Spontaneous hypertensive rats; Heart; Human; Hypertension; Chemotherapy; Polyamine; Treatment; Antihypertensive agent; Cardiovascular disease; Metabolism; Hypertrophy
• ISSN: 0047-1828; 1347-4839
• DOI: 10.1253/jcj.52.1209

In order to assess myocardial hypertrophic activity during the process of hypertensive cardiac hypertrophy in the presence and absence of treatment with anti-hypertensive agents, we analyzed myocardial polyamine concentrations in spontaneous hypertensive (SHR) rats and control rats of Wistar Kyoto (WKY) strain. The anti-hypertensive agents studied were diltiazem, hydralazine and captopril, each of which was administered for 5 weeks. In comparison with WKY rats, SHR rats showed elevated blood pressure and enlarged hearts with higher myocardial spermidine concentration. Although blood pressure was lowered in the diltiazem-treated SHR rats, heart weight and myocardial spermidine concentration increased as in untreated SHR rats. In the hydralazine-treated group increases in both blood pressure and myocardial spermidine concentration were all suppressed. Since spermidine level appears to be a sensitive indicator of hypertrophic activity in the heart, this study suggests that captopril exerts an inhibitory effect on hypertensive cardiac hypertrophy whereas diltiazem does not. It also suggests that hypertrophy may reach a certain plateau level earlier in the hydralazine-treated animals than in others.