Mechanical unloading aggravates bone destruction and tumor expansion in myeloma

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Bibliographic Details
Published inHaematologica (Roma) Vol. 107; no. 3; pp. 744 - 749
Main Authors Tanimoto, Kotaro, Hiasa, Masahiro, Tenshin, Hirofumi, Teramachi, Jumpei, Oda, Asuka, Harada, Takeshi, Higa, Yoshiki, Sogabe, Kimiko, Oura, Masahiro, Sumitani, Ryohei, Hara, Tomoyo, Endo, Itsuro, Matsumoto, Toshio, Tanaka, Eiji, Abe, Masahiro
Format Journal Article
LanguageEnglish
Published Italy Fondazione Ferrata Storti 01.03.2022
Ferrata Storti Foundation
Subjects
Bone Resorption
Humans
Letters to the Editor
Multiple Myeloma - pathology
Osteoclasts
Osteolysis
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Disclosures: MA received research funding from Chugai Pharmaceutical, Sanofi K.K., Pfizer Seiyaku K.K., Kyowa Hakko Kirin, MSD K.K., Astellas Pharma, Takeda Pharmaceutical, Teijin Pharma and Ono Pharmaceutical, and honoraria from Daiichi Sankyo Company. All other authors declare no competing financial interests.
Contributions:KT, MH and MA designed the research and conceived the project; KT, MH, HT, JT, AO, TH, YH, KS, MO and RS conducted animal experiments; TH, IE, TM, ET evaluated muscle and bone specimens; KT, MH, KS, MO and RS conducted in vitro cultures; KT, MH, JT, HT, AO, TH and YH performed immunoblotting and immunohistochemical analyses; KT, MH and AO performed flow cytometric analysis; and KT, MH, JT and HT performed transfection and PCR; KT, MH, IE, TM, ET and MA analyzed the data; KT, MH and MA wrote the manuscript.
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.2021.278295