Philadelphia Chromosome Symposium: commemoration of the 50th anniversary of the discovery of the Ph chromosome
This report summarizes highlights of the Philadelphia Chromosome Symposium: Past, Present and Future, held September 28, 2010, to commemorate the 50th anniversary of the discovery of the Philadelphia chromosome. The symposium sessions included presentations by investigators who made seminal contribu...
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| Published in | Cancer genetics Vol. 204; no. 4; pp. 171 - 179 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
01.04.2011
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| Abstract | This report summarizes highlights of the Philadelphia Chromosome Symposium: Past, Present and Future, held September 28, 2010, to commemorate the 50th anniversary of the discovery of the Philadelphia chromosome. The symposium sessions included presentations by investigators who made seminal contributions concerning the discovery and molecular characterization of the Ph chromosome and others who developed a highly successful therapy based on the specific molecular alteration observed in chronic myeloid leukemia. Additional presentations highlighted future opportunities for the design of molecularly targeted therapies for various types of cancer. Also included here are reminiscences connected with the discovery of the Ph chromosome by David Hungerford and Peter Nowell, the discovery that the abnormality arises from a chromosomal translocation, by Janet Rowley, and the cloning of the 9;22 translocation breakpoints by Nora Heisterkamp, John Groffen, and colleagues. |
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| AbstractList | This report summarizes highlights of the Philadelphia Chromosome Symposium: Past, Present and Future, held September 28, 2010, to commemorate the 50th anniversary of the discovery of the Philadelphia chromosome. The symposium sessions included presentations by investigators who made seminal contributions concerning the discovery and molecular characterization of the Ph chromosome and others who developed a highly successful therapy based on the specific molecular alteration observed in chronic myeloid leukemia. Additional presentations highlighted future opportunities for the design of molecularly targeted therapies for various types of cancer. Also included here are reminiscences connected with the discovery of the Ph chromosome by David Hungerford and Peter Nowell, the discovery that the abnormality arises from a chromosomal translocation, by Janet Rowley, and the cloning of the 9; 22 translocation breakpoints by Nora Heisterkamp, John Groffen, and colleagues. This report summarizes highlights of the ‘Philadelphia Chromosome Symposium: Past, Present and Future’, held September 28, 2010, to commemorate the 50 th anniversary of the discovery of the Philadelphia chromosome. The symposium sessions included presentations by investigators who made seminal contributions concerning the discovery and molecular characterization of the Ph chromosome and others who developed a highly successful therapy based on the specific molecular alteration observed in chronic myelogenous leukemia. Additional presentations highlighted future opportunities for the design of molecularly targeted therapies for various types of cancer. Also included here are reminiscences connected with the discovery of the Ph chromosome by David Hungerford and Peter Nowell, the discovery that the abnormality arises from a chromosomal translocation, by Janet Rowley, and the cloning of the 9;22 translocation breakpoints by Nora Heisterkamp, John Groffen and colleagues. |
| Author | Morrissette, Jennifer J.D Chandra, H. Sharat Hungerford, Alice Rowley, Janet D Heisterkamp, Nora C Nowell, Peter C Testa, Joseph R |
| AuthorAffiliation | f Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111 USA a Centre for Human Genetics, Bangalore, India 560 100 b Division of Hematology-Oncology, Childrens Hospital of Los Angeles, Los Angeles CA 90027 USA c ECRI Institute, Plymouth Meeting, PA 19462 USA e Department of Medicine, University of Chicago, Chicago, IL 60637 USA d Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA |
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| Author_xml | – sequence: 1 fullname: Chandra, H. Sharat – sequence: 2 fullname: Heisterkamp, Nora C – sequence: 3 fullname: Hungerford, Alice – sequence: 4 fullname: Morrissette, Jennifer J.D – sequence: 5 fullname: Nowell, Peter C – sequence: 6 fullname: Rowley, Janet D – sequence: 7 fullname: Testa, Joseph R |
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| Cites_doi | 10.1038/315758a0 10.1016/0014-4827(60)90138-5 10.1073/pnas.82.6.1810 10.1083/jcb.4.4.391 10.1093/oxfordjournals.jhered.a105979 10.1002/jmor.1050970305 10.1016/0092-8674(84)90077-1 10.1038/243290a0 10.1146/annurev.med.53.082901.103519 10.3109/10520296509116440 10.1016/S0140-6736(61)90001-0 10.1126/science.2406902 10.1056/NEJM200104053441401 10.1056/NEJM198512053132301 10.1128/MCB.5.1.204 10.1038/299747a0 10.1016/0092-8674(84)90438-0 10.1016/j.leukres.2003.10.002 10.1038/281396a0 10.1073/pnas.87.17.6649 10.1111/j.1601-5223.1954.tb02968.x 10.1016/S0140-6736(60)92932-9 10.1038/315550a0 10.1038/300765a0 10.1038/306239a0 10.1016/j.ceb.2009.02.001 10.1038/2598 10.1093/oxfordjournals.jhered.a106344 10.1007/0-306-48158-8_6 10.1016/S1535-6108(02)00096-X |
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| Snippet | This report summarizes highlights of the Philadelphia Chromosome Symposium: Past, Present and Future, held September 28, 2010, to commemorate the 50th... This report summarizes highlights of the ‘Philadelphia Chromosome Symposium: Past, Present and Future’, held September 28, 2010, to commemorate the 50 th... |
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| SubjectTerms | Antineoplastic Agents - therapeutic use Benzamides Breakpoints Cloning, Molecular Cytogenetics - history Cytogenetics - methods Cytogenetics - trends Hematology, Oncology and Palliative Medicine History, 20th Century History, 21st Century Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - history Medical Education Philadelphia Chromosome Piperazines - therapeutic use Pyrimidines - therapeutic use Translocation, Genetic |
| Title | Philadelphia Chromosome Symposium: commemoration of the 50th anniversary of the discovery of the Ph chromosome |
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