Philadelphia Chromosome Symposium: commemoration of the 50th anniversary of the discovery of the Ph chromosome

This report summarizes highlights of the Philadelphia Chromosome Symposium: Past, Present and Future, held September 28, 2010, to commemorate the 50th anniversary of the discovery of the Philadelphia chromosome. The symposium sessions included presentations by investigators who made seminal contribu...

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Published inCancer genetics Vol. 204; no. 4; pp. 171 - 179
Main Authors Chandra, H. Sharat, Heisterkamp, Nora C, Hungerford, Alice, Morrissette, Jennifer J.D, Nowell, Peter C, Rowley, Janet D, Testa, Joseph R
Format Journal Article
LanguageEnglish
Published United States 01.04.2011
Subjects
Antineoplastic Agents - therapeutic use
Benzamides
Breakpoints
Cloning, Molecular
Cytogenetics - history
Cytogenetics - methods
Cytogenetics - trends
Hematology, Oncology and Palliative Medicine
History, 20th Century
History, 21st Century
Humans
Imatinib Mesylate
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - history
Medical Education
Philadelphia Chromosome
Piperazines - therapeutic use
Pyrimidines - therapeutic use
Translocation, Genetic
BCR
imatinib
translocation
ABL
targeted therapies
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Summary:This report summarizes highlights of the Philadelphia Chromosome Symposium: Past, Present and Future, held September 28, 2010, to commemorate the 50th anniversary of the discovery of the Philadelphia chromosome. The symposium sessions included presentations by investigators who made seminal contributions concerning the discovery and molecular characterization of the Ph chromosome and others who developed a highly successful therapy based on the specific molecular alteration observed in chronic myeloid leukemia. Additional presentations highlighted future opportunities for the design of molecularly targeted therapies for various types of cancer. Also included here are reminiscences connected with the discovery of the Ph chromosome by David Hungerford and Peter Nowell, the discovery that the abnormality arises from a chromosomal translocation, by Janet Rowley, and the cloning of the 9;22 translocation breakpoints by Nora Heisterkamp, John Groffen, and colleagues.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:2210-7762
DOI:10.1016/j.cancergen.2011.03.002