Inhibitors of Prostaglandin Biosynthesis from Dalbergia odorifera

• Published in: Chem. Pharm. Bull Vol. 40; no. 9; pp. 2452 - 2457
• Main Authors: SHIBUYA, Masaaki, GODA, Yukihiro, KIUCHI, Fumiyuki, SANKAWA, Ushio
• Format: Journal Article
• Language: English
• Published: TOKYO The Pharmaceutical Society of Japan 1992; 公益社団法人日本薬学会; Pharmaceutical Soc Japan; Maruzen; Japan Science and Technology Agency
• Subjects: Biological and medical sciences; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; cinnamylphenol; Cyclooxygenase Inhibitors - isolation & purification; Cyclooxygenase Inhibitors - pharmacology; Dallbergia odorifera; General pharmacology; Humans; In Vitro Techniques; isoflavan; isoflavene; Life Sciences & Biomedicine; Medical sciences; Medicine, East Asian Traditional; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Physical Sciences; Plants, Medicinal - chemistry; Platelet Aggregation - drug effects; platelet aggregation inhibitor; Platelet Aggregation Inhibitors - pharmacology; Prostaglandin Antagonists; prostaglandin biosynthesis inhibitor; pterocarpan; Science & Technology; stagbnant blood; Asia; China; MECHANISM; PROSTAGLANDIN BIOSYNTHESIS INHIBITOR; CINNAMYLPHENOL; ARNEBIFURANONE; STAGNANT BLOOD; PLATELET AGGREGATION INHIBITOR; ISOFLAVONE; PTEROCARPAN; BIOLOGICALLY-ACTIVE CONSTITUENTS; PLANTS; DALBERGIA-ODORIFERA; ARNEBIA-EUCHROMA; ISOFLAVONOID CONSTITUENTS; ISOFLAVAN; Prostaglandin; Root; Pharmacognosy; Arachidonic acid derivatives; Biosynthesis; Extract; Medicinal plant; Aggregation; Platelet; Leguminosae; Folk medicine; Dicotyledones; Angiospermae; Plant origin; Isolation; Spermatophyta; Inhibitor
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.40.2452

he root heartwood of Dalbergia odorifera T. CHEN (Leguminosae) is a Chicese medicinal drug (Japanese name koshinko) used for a stagnant blood syndrome (stagnation of disordered blood; Japanese, oketsu). In addition to 10 known compounds, five new phenolic compounds, isomucronustyrene and hydroxyobtustyrene (cinnamylphenols), (+)-isoduartin (isoflavan), odoriflavene (isoflav-3-ene) and (-)-odoricarpan (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroscopic methods. Of the fifteen compounds isolated, cinnamylphenols, isoflavans, isoflavene and benzoic acid derivative significantly inhibited prostaglandin biosynthesis as well as platelet aggregation induced by arachidonic acid.