Effect of modified-live porcine reproductive and respiratory syndrome virus (PRRSv) vaccine on the shedding of wild-type virus from an infected population of growing pigs

• Published in: Vaccine Vol. 30; no. 2; pp. 407 - 413
• Main Authors: Linhares, Daniel C.L, Cano, Jean Paul, Wetzell, Thomas, Nerem, Joel, Torremorell, Montserrat, Dee, Scott A
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 05.01.2012; Elsevier Limited
• Subjects: Abortion; Aerosols; air; Air filters; Air Microbiology; Allergy and Immunology; Animals; Antibodies, Viral - blood; ATP; Bioaerosols; biosecurity; Blood - virology; blood serum; Enzyme-Linked Immunosorbent Assay; Hogs; industry; Infections; MLV; Mortality; pathogens; Placebos - administration & dosage; porcine reproductive and respiratory syndrome; Porcine Reproductive and Respiratory Syndrome - immunology; Porcine Reproductive and Respiratory Syndrome - prevention & control; Porcine reproductive and respiratory syndrome virus; Porcine respiratory and reproductive syndrome virus; Porcine respiratory and reproductive syndrome virus - genetics; Porcine respiratory and reproductive syndrome virus - immunology; PRRS; quantitative polymerase chain reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA; Saliva - virology; seroconversion; Shedding; Studies; Swine; tonsils; United States; Vaccine; Vaccines; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - genetics; Vaccines, Attenuated - immunology; Veterinary services; viral shedding; Viral Vaccines - administration & dosage; Viral Vaccines - genetics; Viral Vaccines - immunology; viremia; Virus Shedding; viruses; Vitamin E; United States; United States > US; Shedding; Swine; PRRS; MLV; Vaccine; ATP; Bioaerosols
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.10.075

Highlights ► PRRSv is disseminated in regions via infectious bioaerosols. ► We evaluated modified-live virus (MLV) vaccine on PRRSv shedding and dissemination. ► MLV vaccine reduces PRRSv dissemination from populations previously PRRSv-infected. ► Challenge-vaccine group had significant reduction in cumulative PRRSv shed in the air. ► MLV vaccine is a tool to decrease PRRSv regional dissemination.