GBCdb: RNA expression landscapes and ncRNA–mRNA interactions in gallbladder carcinoma

• Published in: BMC bioinformatics Vol. 24; no. 1; pp. 12 - 10
• Main Authors: Guo, Li, Xiang, Yangyang, Dou, Yuyang, Yin, Zibo, Xu, Xinru, Tang, Lihua, Yu, Jiafeng, Wang, Jun, Liang, Tingming
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.01.2023; BioMed Central; BMC
• Subjects: Analysis; Cell Line, Tumor; Diagnosis; Expression landscape; Gallbladder cancer; Gallbladder carcinoma (GBC); Gallbladder Neoplasms - genetics; Gallbladder Neoplasms - metabolism; Gallbladder Neoplasms - pathology; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; Humans; Multi-omics; RNA; RNA interaction; RNA, Long Noncoding - genetics; RNA, Messenger - genetics; RNA, Untranslated - genetics; China; Gallbladder carcinoma (GBC); RNA interaction; Expression landscape; Multi-omics
• ISSN: 1471-2105; 1471-2105
• DOI: 10.1186/s12859-023-05133-2

Gallbladder carcinoma (GBC), an aggressive malignant tumor of the biliary system, is characterized by high cellular heterogeneity and poor prognosis. Fewer data have been reported in GBC than other common cancer types. Multi-omics data will contribute to the understanding of the molecular mechanisms of cancer, cancer diagnosis and prognosis. Herein, to provide better understanding of the molecular events in GBC pathogenesis, we developed GBCdb ( http://tmliang.cn/gbc/ ), a user-friendly interface for the query and browsing of GBC-associated genes and RNA interaction networks using published multi-omics data, which also included experimentally supported data from different molecular levels. GBCdb will help to elucidate the potential biological roles of different RNAs and allow for the exploration of RNA interactions in GBC. These resources will provide an opportunity for unraveling the potential molecular features of Gallbladder carcinoma.