An Ultrasensitive Biomimetic Optic Afferent Nervous System with Circadian Learnability

• Published in: Advanced science Vol. 11; no. 21; pp. e2309489 - n/a
• Main Authors: Wang, Kaiyang, Ren, Shuhui, Jia, Yunfang, Yan, Xiaobing
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.06.2024; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Behavior; Biological clocks; Biomimetics - methods; Circadian rhythm; Circadian Rhythm - physiology; Electrodes; heterojunction; Humans; Light; Nervous system; Neural Networks, Computer; neurotransmitter; Neurotransmitters; optic afferent nervous system; Optics; Photochemistry; Serotonin; synapse; Visual perception; synapse; neurotransmitter; heterojunction; optic afferent nervous system; circadian rhythm
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202309489

The optic afferent nervous system (OANS) plays a significant role in generating vision and circadian behaviors based on light detection and signals from the endocrine system. However, the bionic simulation of this photochemically mediated behavior is still a challenge for neuromorphic devices. Herein, stimuli of neurotransmitters at ultralow concentrations and illumination are coupled to artificial synapses with the aid of biofunctionalized heterojunction and tunneling to successfully simulate a circadian neural response. Furthermore, the mechanisms underlying the photosensitive synaptic current in response to stimuli are described. Interestingly, this OANS is demonstrated to be capable of mimicking normal and abnormal circadian learnability by combining the measured synaptic current with a three‐layer spike neural network. Strong theoretical and experimental evidence, as well as applications, are provided for the proposed biomimetic OANS to demonstrate that it can reproduce biological circadian behavior, thus establishing it as a promising candidate for future neuromorphic intelligent robots. A biomimetic optic afferent nervous system is proposed to mimic circadian rhythm by constructing biochemical and photosensitive interfaces on the traditional MXene synapse. The experimental and theoretical studies are elaborately conducted to demonstrate its sensitivities for light and serotonin. It can not only simulate the synaptic plasticity modulated by serotonin and light but also the circadian learning behaviors.