Hepatitis A vaccine response in HIV-infected patients: Are TWINRIX® and HAVRIX® interchangeable?

• Published in: Vaccine Vol. 31; no. 9; pp. 1328 - 1333
• Main Authors: Jimenez, Humberto R, Hallit, Rabih R, DeBari, Vincent A, Slim, Jihad
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 18.02.2013; Elsevier; Elsevier Limited
• Subjects: Adult; Allergy and Immunology; Antiretroviral drugs; Applied microbiology; Biological and medical sciences; CD4 Lymphocyte Count; Drug therapy; enzyme-linked immunosorbent assay; Female; Fundamental and applied biological sciences. Psychology; guidelines; Hepatitis; Hepatitis A; Hepatitis A - immunology; Hepatitis A - prevention & control; Hepatitis A Antibodies - blood; Hepatitis A Vaccines - administration & dosage; Hepatitis A Vaccines - immunology; Hepatitis A virus; hepatitis B; Hepatitis B Vaccines - administration & dosage; Hepatitis B Vaccines - immunology; HIV; HIV - isolation & purification; HIV infections; HIV Infections - immunology; Human immunodeficiency virus; Human viral diseases; Humans; immune response; Infectious diseases; Male; Medical sciences; Microbiology; Middle Aged; patients; people; Response; Retrospective Studies; risk; RNA; RNA, Viral - blood; Seroconversion; Vaccination; Vaccine; vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Combined - administration & dosage; Vaccines, Combined - immunology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral hepatitis; Viral Load; Response; Vaccine; HIV; Seroconversion; Vaccination; Hepatitis A; Immunopathology; Retroviridae; Hepatic disease; AIDS; Immune deficiency; Lentivirus; Infection; Virus; Viral hepatitis A; Viral disease; Digestive diseases; Human immunodeficiency virus
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2012.12.045

Highlights ► We assessed the impact of factors on Hepatitis A vaccine response in HIV patients. ► Seroconversion occurred in 54% of the HIV-infected patients receiving Hep A vaccine. ► Responders had higher CD4 counts and lower viral loads than non-responders. ► Viral suppression and vaccine series completion impacted TWINRIX® more than HAVRIX® . ► HAVRIX® and TWINRIX® may not be interchangeable in HIV-infected patients.