A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA

• Published in: PloS one Vol. 9; no. 11; p. e113476
• Main Authors: Márquez, Ana, Solans, Roser, Hernández-Rodríguez, José, Cid, Maria C, Castañeda, Santos, Ramentol, Marc, Rodriguez-Rodriguez, Luis, Narváez, Javier, Blanco, Ricardo, Ortego-Centeno, Norberto, Palm, Oyvind, Diamantopoulos, Andreas P, Braun, Niko, Moosig, Frank, Witte, Torsten, Beretta, Lorenzo, Lunardi, Claudio, Cimmino, Marco A, Vaglio, Augusto, Salvarani, Carlo, González-Gay, Miguel A, Martín, Javier
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.11.2014; Public Library of Science (PLoS)
• Subjects: Alleles; Angiogenesis; Arteries; Arteritis; Arteritis de cèl·lules gegants; Asthma; Authorship; Autoimmune diseases; Biology and Life Sciences; Biopsy; Cardiovascular disease; Case-Control Studies; Celiac disease; Cohort Studies; Consortia; Coronary vessels; Crohns disease; Disease Susceptibility; Female; Gene expression; Gene frequency; Gene polymorphism; Gene Regulatory Networks; Genetic diversity; Genetic Loci; Genetic variance; Genomes; Genotype; Genètica mèdica; Giant cell arteritis; Giant Cell Arteritis - genetics; Giant Cell Arteritis - pathology; Hospitals; Humans; Inflammation; Inflammatory bowel disease; Interleucines; Interleukin 1; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33 - genetics; Interleukins; Internal medicine; Male; Medical genetics; Medicine; Meta-analysis; Nephrology; Odds Ratio; Patients; Polymorphism; Polymorphism, Single Nucleotide; Receptors, Cell Surface - genetics; Rheumatoid arthritis; Rheumatology; Risk Factors; Statistical analysis; Studies; Systemic diseases; Italy; Norway; Germany; Spain
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0113476

Increased expression of IL-33 and its receptor ST2, encoded by the IL1RL1 gene, has been detected in the inflamed arteries of giant cell arteritis (GCA) patients. The aim of the present study was to investigate for the first time the potential influence of the IL33 and IL1RL1 loci on GCA predisposition. A total of 1,363 biopsy-proven GCA patients and 3,908 healthy controls from four European cohorts (Spain, Italy, Germany and Norway) were combined in a meta-analysis. Six genetic variants: rs3939286, rs7025417 and rs7044343, within the IL33 gene, and rs2058660, rs2310173 and rs13015714, within the IL1RL1 gene, previously associated with immune-related diseases, were genotyped using predesigned TaqMan assays. A consistent association between the rs7025417 polymorphism and GCA was evident in the overall meta-analysis, under both allele (P(MH) = 0.041, OR = 0.88, CI 95% 0.78-0.99) and recessive (P(MH) = 3.40E-03, OR = 0.53, CI 95% 0.35-0.80) models. No statistically significant differences between allele or genotype frequencies for the other IL33 and IL1RL1 genetic variants were detected in this pooled analysis. Our results clearly evidenced the implication of the IL33 rs7025417 polymorphism in the genetic network underlying GCA.