Biomarkers in volunteers exposed to mobile phone radiation

• Published in: Toxicology letters Vol. 235; no. 2; pp. 140 - 146
• Main Authors: Söderqvist, Fredrik, Carlberg, Michael, Hardell, Lennart
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.06.2015
• Subjects: Adolescent; Adult; beta-trace protein; Biomarkers; Biomarkers - blood; Blood; Blood-brain barrier; Blood-Brain Barrier - metabolism; Blood-Brain Barrier - radiation effects; Cell Phone; Cell phones; Cordless phones; Exposure; Female; Humans; Intramolecular Oxidoreductases - blood; Lipocalins - blood; Male; Medicin; Medicine; Microwaves; Microwaves - adverse effects; Non-ionizing radiation; Prealbumin - metabolism; Proteins; Radiofrequency fields; Risk Assessment; S100 beta; S100 Calcium Binding Protein beta Subunit - blood; S100β, β-trace protein; Sampling; Serums; Single-Blind Method; Sleep; Sweden; Tandomized trial; Time Factors; Transthyretin; Young Adult; Tandomized trial; Sleep; Transthyretin; Non-ionizing radiation; Radiofrequency fields; S100β, β-trace protein; Cordless phones; Blood–brain barrier; β-trace protein; Blood-brain barrier; S100β
• ISSN: 0378-4274; 1879-3169; 1879-3169
• DOI: 10.1016/j.toxlet.2015.03.016

•This single blinded randomized counterbalanced study tested whether short term exposure to an 890-MHz phone-like signal affects the integrity of brain-shielding barriers.•The study had multiple exposure conditions and included 24 healthy subjects aged 18–30 years.•Biomarkers analyzed in blood serum before and after the three different exposure conditions were used to evaluate potential effects.•The study failed to show any clinically or statistically significant effect of short term microwave exposure on the serum levels of S100β, TTR and β-trace protein with a follow up limited to two hours. For some time it has been investigated whether low-intensity non-thermal microwave radiation from mobile phones adversely affects the mammalian blood–brain barrier (BBB). All such studies except one have been either in vitro or experimental animal studies. The one carried out on humans showed a statistically significant increase in serum transthyretin (TTR) 60min after finishing of a 30-min microwave exposure session. The aim of the present study was to follow up on the finding of the previous one using a better study design. Using biomarkers analyzed in blood serum before and after the exposure this single blinded randomized counterbalanced study, including 24 healthy subjects aged 18–30 years that all underwent three exposure conditions (SAR10G=2W/kg, SAR10G=0.2W/kg, sham), tested whether microwaves from an 890-MHz phone-like signal give acute effects on the integrity of brain-shielding barriers. Over time, statistically significant variations were found for two of the three biomarkers (TTR; β-trace protein); however, no such difference was found between the different exposure conditions nor was there any interaction between exposure condition and time of blood sampling. In conclusion this study failed to show any acute clinically or statistically significant effect of short term microwave exposure on the serum levels of S100β, TTR and β-trace protein with a follow up limited to two hours. The study was hampered by the fact that all study persons were regular wireless phone users and thus not naïve as to microwave exposure.