Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis

Because PGD2 is released by several cell types important to allergic inflammation including mast cells, macrophages, and eosinophils, activation of these cell types at mucosal sites in the upper or lower airway could promote PGD2-mediated chemotaxis in tissues.

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 133; no. 3; pp. 899 - 901.e3
Main Authors Chang, Jinny E., MD, Doherty, Taylor A., MD, Baum, Rachel, BS, Broide, David, MB, ChB
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.03.2014
Elsevier
Elsevier Limited
Subjects
Allergies
Allergy and Immunology
Biological and medical sciences
Chemotaxis, Leukocyte
Cytokines
Experiments
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunity, Innate
Immunopathology
Lymphocytes
Lymphocytes - immunology
Lymphocytes - pathology
Medical sciences
Prostaglandin D2 - physiology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Studies
Human
Immunopathology
Lymphoid cell
Regulation(control)
Immunology
Prostaglandin D2
Chemotaxis
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Summary:Because PGD2 is released by several cell types important to allergic inflammation including mast cells, macrophages, and eosinophils, activation of these cell types at mucosal sites in the upper or lower airway could promote PGD2-mediated chemotaxis in tissues.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-1
content type line 63
ObjectType-Correspondence-2
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2013.09.020