The prevalence of BRCA1 and BRCA2 mutations among young Mexican women with triple-negative breast cancer
Various guidelines recommend that women with triple-negative breast cancer should be tested for BRCA1 mutations, but the prevalence of mutations may vary with ethnic group and with geographic region, and the optimal cutoff age for testing has not been established. We estimated the frequencies of BRC...
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Published in | Breast cancer research and treatment Vol. 150; no. 2; pp. 389 - 394 |
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Main Authors | , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Boston
Springer US
01.04.2015
Springer Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Various guidelines recommend that women with triple-negative breast cancer should be tested for
BRCA1
mutations, but the prevalence of mutations may vary with ethnic group and with geographic region, and the optimal cutoff age for testing has not been established. We estimated the frequencies of
BRCA1
and
BRCA2 (BRCA)
mutations among 190 women with triple-negative breast cancer, unselected for family history, diagnosed at age 50 or less at a single hospital in Mexico City. Patients were screened for 115 recurrent
BRCA
mutations, which have been reported previously in women of Hispanic origin, including a common large rearrangement Mexican founder mutation (
BRCA1
ex9-12del). A
BRCA
mutation was detected in 44 of 190 patients with triple-negative breast cancer (23 %). Forty-three mutations were found in
BRCA1
and one mutation was found in
BRCA2
. Seven different mutations accounted for 39 patients (89 % of the total mutations). The Mexican founder mutation (
BRCA1
ex9-12del) was found 18 times and accounted for 41 % of all mutations detected. There is a high prevalence of
BRCA1
mutations among young triple-negative breast cancer patients in Mexico. Women with triple-negative breast cancer in Mexico should be screened for mutations in
BRCA1
. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Villarreal-Garza C and Weitzel JN have authors contributed equally to this study. |
ISSN: | 0167-6806 1573-7217 |
DOI: | 10.1007/s10549-015-3312-8 |