Buccinator muscle invasion is a risk factor for cervical lymph node metastasis in squamous cell carcinoma of the buccal mucosa: A retrospective study

• Published in: Oncology letters Vol. 25; no. 6; p. 226
• Main Authors: Hirai, Hideaki, Nishii, Naoto, Oikawa, Yu, Ohsako, Toshimitsu, Kugimoto, Takuma, Kuroshima, Takeshi, Tomioka, Hirofumi, Michi, Yasuyuki, Kayamori, Kou, Ikeda, Tohru, Harada, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.06.2023; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Clinical outcomes; Dissection; Lymphatic system; Medical prognosis; Medical research; Medicine, Experimental; Metastasis; Neck; Oncology; Patients; Radiation therapy; Regression analysis; Risk factors; Squamous cell carcinoma; Surgery; Japan; buccal mucosa; buccinator muscle; cervical lymph node metastasis; elective neck dissection; squamous cell carcinoma
• ISSN: 1792-1074; 1792-1082
• DOI: 10.3892/ol.2023.13812

The present study aimed to determine the risk factors associated with cervical lymph node metastasis (CLNM) in patients with buccal mucosa squamous cell carcinoma (BMSCC). This retrospective study included patients with primary BMSCC who underwent surgery at the Department of Oral and Maxillofacial Surgical Oncology of Tokyo Medical and Dental University (Tokyo, Japan) between January 2008 and December 2017. The following data were collected and analyzed: Sex, age, primary lesion subsite, tumor/node/metastasis stage, clinical growth patterns, tumor differentiation, lymphovascular and perineural invasion, mode of invasion, pathological depth of invasion, extent of tumor invasion, and clinical outcome of patients with BMSCC. Multivariate analysis was performed to identify the possible risk factors for CLNM. A total of 75 patients were included in the present study, among whom 30 (40%) were found to have histological CLNM. Of the 33 patients with buccinator muscle infiltration by the tumor, 24 (72.7%) had CLNM. Multiple logistic regression analysis revealed that buccinator muscle invasion was the most significant predictive risk factor for CLNM in BMSCC. The present study found that tumor invasion of the buccinator muscle was the most significant predictive risk factor for CLNM in BMSCC. Therefore, elective neck dissection should be performed if buccinator muscle invasion is identified in patients with BMSCC.