REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB)

• Published in: Behavioural neurology Vol. 2018; no. 2018; pp. 1 - 10
• Main Authors: Hu, Chaur-Jong, Hong, Chien-Tai, Lee, Hsun-Hua, Chan, Po-Chi, Wu, Dean
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc; Wiley
• Subjects: Apathy; Armodafinil; Behavior; Behavior disorders; Biomarkers; Cognition & reasoning; Cognitive Dysfunction - complications; Consortia; Dementia; Dementia - complications; Dopamine; Eye movements; Hallucinations; Humans; Lewy Body Disease - complications; Lewy Body Disease - physiopathology; Nervous system diseases; Neurology; Neurosciences; Parkinson Disease - complications; Pathology; Pramipexole; Psychotropic drugs; REM sleep; REM Sleep Behavior Disorder - physiopathology; Review; Sleep; Sleep Wake Disorders - complications; Sleep, REM - physiology
• ISSN: 0953-4180; 1875-8584; 1875-8584
• DOI: 10.1155/2018/9421098

Rapid eye movement sleep behavior disorder (RBD) is a parasomnia, with abnormal dream-enacting behavior during the rapid eye movement (REM) sleep. RBD is either idiopathic or secondary to other neurologic disorders and medications. Dementia with Lewy bodies (DLB) is the third most common cause of dementia, and the typical clinical presentation is rapidly progressive cognitive impairment. RBD is one of the core features of DLB and may occur either in advance or simultaneously with the onset of DLB. The association between RBD with DLB is widely studied. Evidences suggest that both DLB and RBD are possibly caused by the shared underlying synucleinopathy. This review article discusses history, clinical manifestations, possible pathophysiologies, and treatment of DLB and RBD and provides the latest updates.