Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population

• Published in: Nature genetics Vol. 43; no. 4; pp. 345 - 349
• Main Authors: Wang, Fan, Xu, Cheng-Qi, He, Qing, Cai, Jian-Ping, Li, Xiu-Chun, Wang, Dan, Xiong, Xin, Liao, Yu-Hua, Zeng, Qiu-Tang, Yang, Yan-Zong, Cheng, Xiang, Li, Cong, Yang, Rong, Wang, Chu-Chu, Wu, Gang, Lu, Qiu-Lun, Bai, Ying, Huang, Yu-Feng, Yin, Dan, Yang, Qing, Wang, Xiao-Jing, Dai, Da-Peng, Zhang, Rong-Feng, Wan, Jing, Ren, Jiang-Hua, Li, Si-Si, Zhao, Yuan-Yuan, Fu, Fen-Fen, Huang, Yuan, Li, Qing-Xian, Shi, Sheng-Wei, Lin, Nan, Pan, Zhen-Wei, Li, Yue, Yu, Bo, Wu, Yan-Xia, Ke, Yu-He, Lei, Jian, Wang, Nan, Luo, Chun-Yan, Ji, Li-Ying, Gao, Lian-Jun, Li, Lei, Liu, Hui, Huang, Er-Wen, Cui, Jin, Jia, Na, Ren, Xiang, Li, Hui, Ke, Tie, Zhang, Xian-Qin, Liu, Jing-Yu, Liu, Mu-Gen, Xia, Hao, Yang, Bo, Shi, Li-Song, Xia, Yun-Long, Tu, Xin, Wang, Qing K
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.04.2011; Nature Publishing Group
• Subjects: 631/208/205/2138; 631/208/727/2000; 692/699/75/593/15; 692/700/478/174; Agriculture; Alleles; Animal Genetics and Genomics; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; China; Chromosomes, Human, Pair 6 - genetics; Coronary Artery Disease - genetics; Coronary heart disease; Disease susceptibility; Female; Fundamental and applied biological sciences. Psychology; Gene Function; Genetic aspects; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Genomes; Heart attacks; Human; Human Genetics; Humans; Hypertension; letter; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide; Population genetics, reproduction patterns; Regression analysis; Risk Factors; RNA, Messenger - genetics; Single nucleotide polymorphisms; Asia; China; Far east; Vascular disease; Human; Cardiovascular disease; Population genetics; Ethnic group; Atherosclerosis
• ISSN: 1061-4036; 1546-1718
• DOI: 10.1038/ng.783

Qing Wang and colleagues report a genome-wide association study for coronary artery disease (CAD) in a Chinese Han population. They identify a locus on chromosome 6p24.1 newly associated with CAD. Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted as C6orf105 on chromosome 6p24.1 and CAD ( P = 5.00 × 10 −3 , stage 2 validation; P = 3.00 × 10 −3 , P = 1.19 × 10 −8 and P = 4.00 × 10 −3 in three independent stage 3 replication populations; P = 4.87 × 10 −12 , odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreased C6orf105 mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, in C6orf105 associated with susceptibility to CAD in this population.