Assessment of the predictive role of pretreatment Ki-67 and Ki-67 changes in breast cancer patients receiving neoadjuvant chemotherapy according to the molecular classification: a retrospective study of 1010 patients

• Published in: Breast cancer research and treatment Vol. 170; no. 1; pp. 35 - 43
• Main Authors: Chen, Rui, Ye, Yin, Yang, Chengcheng, Peng, Yang, Zong, Beige, Qu, Fanli, Tang, Zhenrong, Wang, Yihua, Su, Xinliang, Li, Hongyuan, Yang, Guanglun, Liu, Shengchun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2018; Springer; Springer Nature B.V
• Subjects: Adjuvant chemotherapy; Adult; Aged; Anthracycline; Anthracyclines; Biomarkers, Tumor - genetics; Breast cancer; Breast Neoplasms - classification; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cancer patients; Cancer research; Chemotherapy; Clinical Trial; ErbB-2 protein; Estrogen Receptor alpha - genetics; Female; Humans; Kaplan-Meier Estimate; Ki-67 Antigen - genetics; Medicine; Medicine & Public Health; Middle Aged; Neoadjuvant Therapy - adverse effects; Oncology; Receptor, ErbB-2 - genetics; Receptors, Progesterone - genetics; Retrospective Studies; Statistical analysis; Triple Negative Breast Neoplasms - classification; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - pathology; Neoadjuvant chemotherapy; Molecular subtypes; Breast cancer; Tumor response; Ki67
• ISSN: 0167-6806; 1573-7217
• DOI: 10.1007/s10549-018-4730-1

Purpose To assess the predictive role of pretreatment ki67 and Ki67 changes in breast cancer (BC) patients treated with neoadjuvant chemotherapy (NAC) in various molecular subtypes. Methods 1010 BC patients who had undergone anthracycline and taxane-based NAC from January 2012 to July 2017 were retrospectively analyzed. Clinical and pathological parameters of the patients were retrieved and the predictive factors for NAC response were evaluated. Results 705 patients showed clinical response (cRes), and 131 patients acquired pathologic complete response (pCR). Patients with higher pretreatment Ki67 (≥ 14%), tumor size ≥ 4 cm, and positive clinical nodal had better clinical therapy response, while patients with negative ER and PR, higher pretreatment Ki67 (≥ 14%), and tumor size < 4 cm were more probable to attain pCR. The pretreatment Ki67 could be used as a predictor of NAC only in luminal subtypes, and 25.5% were identified as an ideal cut-off point to differentiate the cRes from non-cRes cases. Although a decrease in Ki67 had been found in almost all molecular subtypes after NAC, no statistically significant differences were found in the decrease of Ki67 were validated between the cRes and non-cRes group in HER2-rich and triple-negative subtypes ( P  = 0.488 and P  = 0.111, respectively). Conclusions The best cut-off for pretreatment Ki67 in predicting the connection with the tumor size lessening was 25.5% in luminal subtype. Aggressive adjuvant systemic treatments should be considered for patients with HER2-rich and triple-negative subtype who exhibit tumor shrinkage in NAC but still have high levels of Ki67.