Flagellin enhances tumor-specific CD8+ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model

• Published in: Vaccine Vol. 31; no. 37; pp. 3879 - 3887
• Main Authors: Nguyen, Chung Truong, Hong, Seol Hee, Sin, Jeong-Im, Vu, Hong Van Dinh, Jeong, Kwangjoon, Cho, Kyoung Oh, Uematsu, Satoshi, Akira, Shizuo, Lee, Shee Eun, Rhee, Joon Haeng
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 20.08.2013; Elsevier; Elsevier Limited
• Subjects: Adjuvant; adjuvants; Adjuvants, Immunologic - pharmacology; Allergy and Immunology; Animal models; Animals; anticarcinogenic activity; antigens; Applied microbiology; Biological and medical sciences; Breast cancer; Cancer; Cancer Vaccines - genetics; Cancer Vaccines - immunology; Cancer Vaccines - pharmacology; carcinoma; CD8-positive T-lymphocytes; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cervical cancer; Female; Flagellin; Flagellin - genetics; Flagellin - immunology; Flagellin - pharmacology; Fundamental and applied biological sciences. Psychology; Human papillomavirus; Human papillomavirus 16; Humans; immune response; Immune system; Immunization; Immunogenicity; immunomodulation; Immunotherapy; interferon-gamma; Interferon-gamma - metabolism; Lung Neoplasms - pathology; Lung Neoplasms - therapy; lymph nodes; Medical sciences; Mice; Mice, Inbred C57BL; Microbiology; Oncogene Proteins, Viral - genetics; Oncogene Proteins, Viral - immunology; Papillomavirus E7 Proteins - genetics; Papillomavirus E7 Proteins - immunology; Repressor Proteins - genetics; Repressor Proteins - immunology; Rodents; signal transduction; spleen; T-Lymphocytes, Cytotoxic - immunology; T-Lymphocytes, Cytotoxic - metabolism; TLR5; Toll-like receptor 5; Toll-Like Receptor 5 - immunology; Toll-Like Receptor 5 - metabolism; Tumors; vaccination; Vaccine; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Vaccines, Synthetic - pharmacology; Vibrio vulnificus; Flagellin; Adjuvant; Vaccine; TLR5; Cancer; Immunological adjuvant; Immunotherapy; Cellular immunity; Models; Malignant tumor; Tumor cell; CD8 T lymphocyte
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.06.054

Highlights • FlaB potentiates E6/E7 peptide-mediated anti-tumor efficacy. • FlaB enhances E6/E7-specific CTL responses and IFNγ production. • In vivo adjuvant activity of FlaB is mediated by CD8+ cells. • The adjuvant activity of FlaB is dependent on host TLR5 signaling. • FlaB significantly suppresses tumor development in the TC-1 lung metastasis model.