Heart rate in relation to insulin sensitivity and insulin secretion in nondiabetic subjects

Heart rate in relation to insulin sensitivity and insulin secretion in nondiabetic subjects. A Festa , R D'Agostino, Jr , C N Hales , L Mykkänen and S M Haffner Department of Medicine, University of Texas Health Science Center, San Antonio, USA. Abstract OBJECTIVE: Elevated heart rate has been...

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Published inDiabetes care Vol. 23; no. 5; pp. 624 - 628
Main Authors FESTA, A, D'AGOSTINO, R. JR, HALES, C. N, MYKKÄNEN, L, HAFFNER, S. M
Format Journal Article
LanguageEnglish
Published Alexandria, VA American Diabetes Association 01.05.2000
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Summary:Heart rate in relation to insulin sensitivity and insulin secretion in nondiabetic subjects. A Festa , R D'Agostino, Jr , C N Hales , L Mykkänen and S M Haffner Department of Medicine, University of Texas Health Science Center, San Antonio, USA. Abstract OBJECTIVE: Elevated heart rate has been predictive of cardiovascular disease and has been proposed as a global index of the autonomic nervous system influence on the heart. Hyperinsulinism has been shown to trigger sympathetic activity experimentally; however, the clinical and epidemiological data on the association of heart rate with hyperinsulinism and insulin resistance are conflicting. RESEARCH DESIGN AND METHODS: Insulin sensitivity (S(I)) and the acute insulin response (AIR) to glucose were assessed by a frequently sampled intravenous glucose tolerance test and related to resting heart rate in the tri-ethnic nondiabetic population (n = 1,000) of the Insulin Resistance Atherosclerosis Study. RESULTS: Heart rate was related to fasting insulin (r = 0.20), intact proinsulin (r = 0.15), split proinsulin (r = 0.17), and AIR (r = 0.18), and an inverse relation was found between heart rate and S(I) (r = -0.19) (all P values <0.0001, adjusted for age, sex, ethnicity, glucose tolerance status, and smoking). In a multiple linear regression analysis (adjusting for age, sex, ethnicity, clinical center, glucose tolerance status, and smoking), heart rate was significantly and independently associated with AIR, proinsulin, and S(I). CONCLUSIONS: Proinsulin, acute insulin secretion, and S(I) are associated with heart rate in nondiabetic subjects.
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content type line 23
ISSN:0149-5992
1935-5548
DOI:10.2337/diacare.23.5.624