Heart rate in relation to insulin sensitivity and insulin secretion in nondiabetic subjects
Heart rate in relation to insulin sensitivity and insulin secretion in nondiabetic subjects. A Festa , R D'Agostino, Jr , C N Hales , L Mykkänen and S M Haffner Department of Medicine, University of Texas Health Science Center, San Antonio, USA. Abstract OBJECTIVE: Elevated heart rate has been...
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Published in | Diabetes care Vol. 23; no. 5; pp. 624 - 628 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Alexandria, VA
American Diabetes Association
01.05.2000
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Subjects | |
Online Access | Get full text |
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Summary: | Heart rate in relation to insulin sensitivity and insulin secretion in nondiabetic subjects.
A Festa ,
R D'Agostino, Jr ,
C N Hales ,
L Mykkänen and
S M Haffner
Department of Medicine, University of Texas Health Science Center, San Antonio, USA.
Abstract
OBJECTIVE: Elevated heart rate has been predictive of cardiovascular disease and has been proposed as a global index of the
autonomic nervous system influence on the heart. Hyperinsulinism has been shown to trigger sympathetic activity experimentally;
however, the clinical and epidemiological data on the association of heart rate with hyperinsulinism and insulin resistance
are conflicting. RESEARCH DESIGN AND METHODS: Insulin sensitivity (S(I)) and the acute insulin response (AIR) to glucose were
assessed by a frequently sampled intravenous glucose tolerance test and related to resting heart rate in the tri-ethnic nondiabetic
population (n = 1,000) of the Insulin Resistance Atherosclerosis Study. RESULTS: Heart rate was related to fasting insulin
(r = 0.20), intact proinsulin (r = 0.15), split proinsulin (r = 0.17), and AIR (r = 0.18), and an inverse relation was found
between heart rate and S(I) (r = -0.19) (all P values <0.0001, adjusted for age, sex, ethnicity, glucose tolerance status,
and smoking). In a multiple linear regression analysis (adjusting for age, sex, ethnicity, clinical center, glucose tolerance
status, and smoking), heart rate was significantly and independently associated with AIR, proinsulin, and S(I). CONCLUSIONS:
Proinsulin, acute insulin secretion, and S(I) are associated with heart rate in nondiabetic subjects. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0149-5992 1935-5548 |
DOI: | 10.2337/diacare.23.5.624 |