Immune memory in convalescent patients with asymptomatic or mild COVID-19

It is important to evaluate the durability of the protective immune response elicited by primary infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we systematically evaluated the SARS-CoV-2-specific memory B cell and T cell responses in healthy controls and individua...

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Published inCell discovery Vol. 7; no. 1; p. 18
Main Authors Long, Quan-Xin, Jia, Yan-Jun, Wang, Xin, Deng, Hai-Jun, Cao, Xiao-Xia, Yuan, Jun, Fang, Liang, Cheng, Xu-Rong, Luo, Chao, He, An-Ran, Tang, Xiao-Jun, Hu, Jie-li, Hu, Yuan, Tang, Ni, Cai, Xue-Fei, Wang, De-Qiang, Hu, Jie, Qiu, Jing-Fu, Liu, Bei-Zhong, Chen, Juan, Huang, Ai-long
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 25.03.2021
Springer Nature B.V
Nature Publishing Group
Subjects
631/250
631/80/304
Asymptomatic
Asymptomatic infection
Biomedical and Life Sciences
Cell Biology
Cell Culture
Cell Cycle Analysis
Cell Physiology
Coronaviridae
Coronaviruses
COVID-19
Immunological memory
Infections
Life Sciences
Lymphocytes
Lymphocytes B
Lymphocytes T
Memory cells
Nucleocapsids
Peptide libraries
Peripheral blood
Severe acute respiratory syndrome coronavirus 2
Spike glycoprotein
Stem Cells
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Summary:It is important to evaluate the durability of the protective immune response elicited by primary infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we systematically evaluated the SARS-CoV-2-specific memory B cell and T cell responses in healthy controls and individuals recovered from asymptomatic or symptomatic infection approximately 6 months prior. Comparatively low frequencies of memory B cells specific for the receptor-binding domain (RBD) of spike glycoprotein (S) persisted in the peripheral blood of individuals who recovered from infection (median 0.62%, interquartile range 0.48-0.69). The SARS-CoV-2 RBD-specific memory B cell response was detected in 2 of 13 individuals who recovered from asymptomatic infection and 10 of 20 individuals who recovered from symptomatic infection. T cell responses induced by S, membrane (M), and nucleocapsid (N) peptide libraries from SARS-CoV-2 were observed in individuals recovered from coronavirus disease 2019 (COVID-19), and cross-reactive T cell responses to SARS-CoV-2 were also detected in healthy controls.
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ISSN:2056-5968
2056-5968
DOI:10.1038/s41421-021-00250-9