Heightened sympathetic arousal is demonstrated by skin conductance responsivity to auditory stimuli in a small cohort of neonates with opiate withdrawal

• Published in: Brain research bulletin Vol. 138; pp. 106 - 111
• Main Authors: Oji-Mmuo, Christiana N, Gardner, Fumiyuki Chin, Doheny, Kim K
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2018
• Subjects: Acoustic Stimulation - methods; Assessment at discharge; Autonomic Nervous System - drug effects; Cohort Studies; Dose-Response Relationship, Drug; Female; Galvanic Skin Response - drug effects; Gestational Age; Humans; Infant; Male; Morphine - therapeutic use; Narcotics - therapeutic use; Neonatal abstinence syndrome; Neonatal Abstinence Syndrome - drug therapy; Neonatal Abstinence Syndrome - physiopathology; Neurology; Objective assessment; Opioid-Related Disorders - drug therapy; Opioid-Related Disorders - physiopathology; Skin conductance; Sympathetic arousal; NAS; Electrodermal Response (Peaks/s); Inter Quartile Range; NICU; SC; New Born Nursery; SE; EDR; BW; MFM; Modified Finnegan Neonatal Scoring System; GA; NBN; Assessment at discharge; Neonatal Abstinence Syndrome; Objective assessment; Sympathetic arousal; MP; Standard Error; MFNSS; IQR; Neonatal Intensive Care Unit; Gestational Age; Birth Weight; Skin Conductance; Maternal Fetal Medicine; Mean of Peaks (peak amplitude); Skin conductance; Neonatal abstinence syndrome
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/j.brainresbull.2017.06.007

Highlights • Skin conductance is a non-invasive measure of autonomic system function. • Skin conductance was measured in response to an auditory stimulus at discharge. • In NAS, infants that required morphine had higher skin conductance mean of peaks. • Sympathetic arousal in NAS persists underscoring the need for long-term follow up.