Antigenic Analysis of Human Cytomegalovirus Isolates from Japanese Women and Infants

The antigenic differences among human cytomegalovirus (CMV), two laboratory strains (Davis, AD 169), isolates from pregnant women's cervical secretions, mother's milk, infants' throat swabs and urine were analyzed by means of the plaque reduction assay using human sera which were assu...

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Published inMICROBIOLOGY and IMMUNOLOGY Vol. 23; no. 9; pp. 889 - 897
Main Authors Tanaka, Akira, Numazaki, Yoshio
Format Journal Article
LanguageEnglish
Published Australia Blackwell Publishing Ltd 01.09.1979
Center For Academic Publications Japan
Subjects
Antigens, Viral - analysis
Cervix Mucus - microbiology
Cross Reactions
Cytomegalovirus - immunology
Female
Human cytomegalovirus
Humans
Infant
Infant, Newborn
Japan
Jaundice, Neonatal - microbiology
Milk, Human - microbiology
Mouth Mucosa - microbiology
Neutralization Tests
Pregnancy
Urine - microbiology
Japan
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Summary:The antigenic differences among human cytomegalovirus (CMV), two laboratory strains (Davis, AD 169), isolates from pregnant women's cervical secretions, mother's milk, infants' throat swabs and urine were analyzed by means of the plaque reduction assay using human sera which were assumed to contain monotypic antibodies by primary infection and boosted antibodies by reinfection or reactivation of the latent virus. In the cross-neutralization tests, there were no remarkable differences among the CMV strains examined. Moreover, in the neutralization kinetics, normalized k values among the strains constantly exceeded 80. Therefore, it is suggested that the human CMV strains examined in the study were serologically identical or very closely related.
Bibliography:ark:/67375/WNG-7BZZTKD9-R
Ministry of Health and Welfare of Japan
istex:A0025926BD5F2C907D8524F277521B1ADB78C5C9
ArticleID:MIM02822
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.1979.tb02822.x