L-［S-11C-甲基］-蛋氨酸的合成及 HPLC分析

O615.4%R817; 采用还原碘化法合成11CH3I ，固相法合成11C‐MET ，HPLC分析产品放化纯度，并合成11CH3OH和11CH3I ，利用HPLC分析验证11C‐MET中杂质的成分，探讨溶解前体的NaOH浓度和有机溶剂用量对11C‐MET质量的影响。结果表明，先用0.1 mL 2 mol／L NaOH溶解前体，再与0.1 mL无水乙醇混匀后装入C18柱，可以提高11 C‐M ET的产率及放化纯度。...

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Bibliographic Details
Published in同位素 Vol. 27; no. 4; pp. 236 - 240
Main Author 张晓军 李云刚 刘健 张锦明 田嘉禾
Format Journal Article
LanguageChinese
Published 中国人民解放军总医院核医学科,北京,100853 2014
Subjects
L-[S-11C-甲基]-蛋氨酸
合成
杂质
synthesis
合成
impurity
L-[S-11C-甲基]-蛋氨酸
杂质
HPLC
L-[S-methyl-11 C]Methionine
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ISSN1000-7512
DOI10.7538/tws.2014.27.04.0236

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Summary:O615.4%R817; 采用还原碘化法合成11CH3I ，固相法合成11C‐MET ，HPLC分析产品放化纯度，并合成11CH3OH和11CH3I ，利用HPLC分析验证11C‐MET中杂质的成分，探讨溶解前体的NaOH浓度和有机溶剂用量对11C‐MET质量的影响。结果表明，先用0.1 mL 2 mol／L NaOH溶解前体，再与0.1 mL无水乙醇混匀后装入C18柱，可以提高11 C‐M ET的产率及放化纯度。
Bibliography:11-2566/TL
HPLC;L-[S-methyl-11 C]Methionine;synthesis;HPLC;impurity
11C‐MET was synthesized by the solid phase reaction of 11CH3I and precursor L‐homocysteine ,and the radiochemical purity of 11C‐MET was analyzed by HPLC ,11C‐methanol and 11C‐methyl iodide were prepared and analyzed ,respectively .The primary impurity of the product were analyzed . The influence on the quality of product was investigated by changing the concentration of sodium hydroxide solution and the solvent of dissolving precursor .The results showed that 11C‐MET with higher yield and good radiochemical purity would obtain by using 0.1 mL 2 mol/L NaOH to dissolve the pre‐cursor ,then injecting it into the C18 column after blending 0.1 mL ethanol .
ZHANG Xiao-jun, LI Yun-gang, LIU Jian, ZHANG Jin-ming, TIAN Jia-he （Department of Nuclear Medicine, The PLA General Hospital, Beijing 100853, China）
ISSN:1000-7512
DOI:10.7538/tws.2014.27.04.0236