PET/CT联合显像在雌激素与阿尔茨海默病相关性研究中的价值
通过研究不同雌二醇（estradiol,E2）水平阿尔茨海默病（AD）患者血清中肿瘤坏死因子-α（Tumor necrosis factor-α,TNF-α）及载脂蛋白E（ApoE）的表达,探讨11 C-PIB、18F-FDG PET/CT联合显像对AD的诊断价值。分析绝经后女性AD患者75例,依据雌激素水平分为低E2组（E2〈16.2 pmol/L,n=36）、正常E2组（16.2pmol/L≤E2〈65.7pmol/L,n=39）。检测两组患者血清中ApoE等位基因（ε2、ε3、ε4）表达率、TNF-α表达水平以及PET/CT脑显像标准化摄取比值（standard uptake radio...
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| Published in | 同位素 Vol. 30; no. 4; pp. 276 - 282 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
沈阳军区总医院核医学科,辽宁沈阳,110016%沈阳军区总医院神经内科,辽宁沈阳,110016
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-7512 |
| DOI | 10.7538/tws.2017.youxian.035 |
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| Abstract | 通过研究不同雌二醇（estradiol,E2）水平阿尔茨海默病（AD）患者血清中肿瘤坏死因子-α（Tumor necrosis factor-α,TNF-α）及载脂蛋白E（ApoE）的表达,探讨11 C-PIB、18F-FDG PET/CT联合显像对AD的诊断价值。分析绝经后女性AD患者75例,依据雌激素水平分为低E2组（E2〈16.2 pmol/L,n=36）、正常E2组（16.2pmol/L≤E2〈65.7pmol/L,n=39）。检测两组患者血清中ApoE等位基因（ε2、ε3、ε4）表达率、TNF-α表达水平以及PET/CT脑显像标准化摄取比值（standard uptake radio,SUVR）。研究发现,在不同E2组AD患者中,低E2组^18F-FDG联合11 C-PIB及单独11 C-PIB脑显像诊断AD的灵敏度均较正常E2组高,差异显著（χ^2=4.869,P=0.027;χ^2=3.636,P=0.047）;AD患者E2水平与SUVR及TNF-α表达水平均呈负相关关系（r=-0.363,P=0.001;r=-0.248,P=0.032）,而SUVR及TNF-α表达水平之间无明显相关性（r=0.161,P=0.168）;低E2水平AD患者组ApoE等位基因表达率高,差异显著（Z=-2.228,P=0.026）。结果表明,~（11）C-PIB和^18F-FDG联合显像对AD患者具有较高的诊断价值。 |
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| AbstractList | 通过研究不同雌二醇（estradiol,E2）水平阿尔茨海默病（AD）患者血清中肿瘤坏死因子-α（Tumor necrosis factor-α,TNF-α）及载脂蛋白E（ApoE）的表达,探讨11 C-PIB、18F-FDG PET/CT联合显像对AD的诊断价值。分析绝经后女性AD患者75例,依据雌激素水平分为低E2组（E2〈16.2 pmol/L,n=36）、正常E2组（16.2pmol/L≤E2〈65.7pmol/L,n=39）。检测两组患者血清中ApoE等位基因（ε2、ε3、ε4）表达率、TNF-α表达水平以及PET/CT脑显像标准化摄取比值（standard uptake radio,SUVR）。研究发现,在不同E2组AD患者中,低E2组^18F-FDG联合11 C-PIB及单独11 C-PIB脑显像诊断AD的灵敏度均较正常E2组高,差异显著（χ^2=4.869,P=0.027;χ^2=3.636,P=0.047）;AD患者E2水平与SUVR及TNF-α表达水平均呈负相关关系（r=-0.363,P=0.001;r=-0.248,P=0.032）,而SUVR及TNF-α表达水平之间无明显相关性（r=0.161,P=0.168）;低E2水平AD患者组ApoE等位基因表达率高,差异显著（Z=-2.228,P=0.026）。结果表明,~（11）C-PIB和^18F-FDG联合显像对AD患者具有较高的诊断价值。 R447; 通过研究不同雌二醇(estradiol,E2)水平阿尔茨海默病(AD)患者血清中肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)及载脂蛋白E(ApoE)的表达,探讨11C-PIB、18 F-FDG PET/CT联合显像对AD的诊断价值.分析绝经后女性AD患者75例,依据雌激素水平分为低E2组(E2<16.2 pmol/L,n=36)、正常E2组(16.2 pmol/L≤E2<65.7 pmol/L,n=39).检测两组患者血清中ApoE等位基因(ε2、ε3、ε4)表达率、TNF-α表达水平以及PET/CT脑显像标准化摄取比值(standard uptake radio,SUVR).研究发现,在不同E2组AD患者中,低E2组18F-FDG联合11C-PIB及单独11C-PIB脑显像诊断AD的灵敏度均较正常E2组高,差异显著(χ2=4.869,P=0.027;χ2=3.636,P=0.047);AD患者E2水平与SUVR及TNF-α表达水平均呈负相关关系(r=-0.363,P=0.001;r=-0.248,P=0.032),而SUVR及TNF-α表达水平之间无明显相关性(r=0.161,P=0.168);低E2水平AD患者组ApoE等位基因表达率高,差异显著(Z=-2.228,P=0.026).结果表明,11 C-PIB和18 F-FDG联合显像对AD患者具有较高的诊断价值. |
| Abstract_FL | The expressions of aplipoprotein E (ApoE) ,tumor necrosis factor-α(TNF-α) in Alzheimer's disease (AD) patients with different levels of estrogen were investigated to evaluate the diagnosis of combined PET/CT imaging (11 C-PIB and 18 F-FDG) on AD . A total of 75 female AD patients were divided into low level of estradiol group (E2 <16.2 pmol/L ,n=36) and normal level of estradiol group (16.2 pmol/L≤E2 <65.7 pmol/L , n=39) according to their estradiol levels .All the patients underwent PET/CT imaging (11 C-PIB and 18 F-FDG) .The sensitivity of PET/CT imaging ,the standard uptake value radio ,the expression rates of subtype ApoE (ε2 ,ε3 ,ε4) ,and the expression levels of TNF-α were detected .The relationship between E2 and the expression rates of ApoE , the levels of TNF-αand SUVR were analyzed by Pearson analysis .In the low level of E2 group ,the sensitivity of PET/CT for 11 C-PIB alone ,11 C-PIB combined with 18 F-FDG was higher than in normal E2 group (χ2 =4.869 , P=0.027 ;χ2 =3.636 , P=0.047);while the sensitivity of 18 F-FDG PET/CT imagings on brain between the two groups had no significant difference (χ2 = 2.007 , P= 0.157) .The expression level of E2 with SUVR and the expression level of TNF-αin two groups of AD patients had the negative correlations (r= -0.363 ,P=0.001 ;r= -0.248 ,P=0.032) .The expression rate of ApoEε4 allelic genes of AD patients was higher than that of ε2 andε3 allelic genes ,and there was higher expression rates of ApoE in AD patients with the low E2 group (Z=-2.228 ,P=0.026) .11C-PIB and 18 F-FDG PET/CT had high value of diagnosis in AD patients . |
| Author | 陆国秀;张国旭;郝珊瑚;郭佳;张文文;王治国;张景华 |
| AuthorAffiliation | 沈阳军区总医院核医学科,辽宁沈阳110016;沈阳军区总医院神经内科,辽宁沈阳110016 |
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| Author_FL | ZHANG Guo-xu WANG Zhi-guo ZHANG Jing-hua ZHANG Wen-wen HAO Shan-hu GUO Jia LU Guo-xiu |
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| DOI | 10.7538/tws.2017.youxian.035 |
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| DocumentTitleAlternate | The Value of PET/CT Imaging in Alzheimer＇s Disease Patients with Different Levels of Estradiol |
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| Keywords | 载脂蛋白E tumor necrosis factor-α 雌二醇 apolipoprotein E 阿尔茨海默病 肿瘤坏死因子-α Alzheimer's disease estradiol |
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| Notes | 11-2566/TL Alzheimer’s disease; estradiol; apolipoproteinE; tumor necrosis factor-α The expressions of aplipoprotein E（ApoE）,tumor necrosis factor-α（TNF-α）in Alzheimer＇s disease（AD）patients with different levels of estrogen were investigated to evaluate the diagnosis of combined PET/CT imaging（11 C-PIB and 18 F-FDG）on AD.A total of 75 female AD patients were divided into low level of estradiol group（E2〈16.2 pmol/L,n=36）and normal level of estradiol group（16.2 pmol/L≤E265.7 pmol/L,n=39）according to their estradiol levels.All the patients underwent PET/CT imaging（11 C-PIB and 18 F-FDG）.The sensitivity of PET/CT imaging,the standard uptake value radio,the expression rates of subtype ApoE（ε2,ε3,ε4）,and the expression levels of TNF-αwere detected.The relationship between E2 and the expression rates of ApoE,the levels of TNF-αand SUVR were analyzed by Pearson analysis.In the low level of E2 group,the sensitivity of PET/CT for 11 C-PIB alone,11 C-PIB combined with 18 F-FDG was higher than in normal E2 group（χ^2=4.869, |
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| Publisher | 沈阳军区总医院核医学科,辽宁沈阳,110016%沈阳军区总医院神经内科,辽宁沈阳,110016 |
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| Snippet | 通过研究不同雌二醇（estradiol,E2）水平阿尔茨海默病（AD）患者血清中肿瘤坏死因子-α（Tumor necrosis factor-α,TNF-α）及载脂蛋白E（ApoE）的表达,探讨11 C-PIB、18F-FDG... R447; 通过研究不同雌二醇(estradiol,E2)水平阿尔茨海默病(AD)患者血清中肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)及载脂蛋白E(ApoE)的表达,探讨11C-PIB、18 F-FDG... |
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| StartPage | 276 |
| SubjectTerms | 肿瘤坏死因子-α 载脂蛋白E 阿尔茨海默病 雌二醇 |
| Title | PET/CT联合显像在雌激素与阿尔茨海默病相关性研究中的价值 |
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