PET/CT联合显像在雌激素与阿尔茨海默病相关性研究中的价值

通过研究不同雌二醇（estradiol,E2）水平阿尔茨海默病（AD）患者血清中肿瘤坏死因子-α（Tumor necrosis factor-α,TNF-α）及载脂蛋白E（ApoE）的表达,探讨11 C-PIB、18F-FDG PET/CT联合显像对AD的诊断价值。分析绝经后女性AD患者75例,依据雌激素水平分为低E2组（E2〈16.2 pmol/L,n=36）、正常E2组（16.2pmol/L≤E2〈65.7pmol/L,n=39）。检测两组患者血清中ApoE等位基因（ε2、ε3、ε4）表达率、TNF-α表达水平以及PET/CT脑显像标准化摄取比值（standard uptake radio...

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Bibliographic Details
Published in同位素 Vol. 30; no. 4; pp. 276 - 282
Main Author 陆国秀;张国旭;郝珊瑚;郭佳;张文文;王治国;张景华
Format Journal Article
LanguageChinese
Published 沈阳军区总医院核医学科,辽宁沈阳,110016%沈阳军区总医院神经内科,辽宁沈阳,110016 2017
Subjects
肿瘤坏死因子-α
载脂蛋白E
阿尔茨海默病
雌二醇
载脂蛋白E
tumor necrosis factor-α
雌二醇
apolipoprotein E
阿尔茨海默病
肿瘤坏死因子-α
Alzheimer's disease
estradiol
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ISSN1000-7512
DOI10.7538/tws.2017.youxian.035

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Summary:通过研究不同雌二醇（estradiol,E2）水平阿尔茨海默病（AD）患者血清中肿瘤坏死因子-α（Tumor necrosis factor-α,TNF-α）及载脂蛋白E（ApoE）的表达,探讨11 C-PIB、18F-FDG PET/CT联合显像对AD的诊断价值。分析绝经后女性AD患者75例,依据雌激素水平分为低E2组（E2〈16.2 pmol/L,n=36）、正常E2组（16.2pmol/L≤E2〈65.7pmol/L,n=39）。检测两组患者血清中ApoE等位基因（ε2、ε3、ε4）表达率、TNF-α表达水平以及PET/CT脑显像标准化摄取比值（standard uptake radio,SUVR）。研究发现,在不同E2组AD患者中,低E2组^18F-FDG联合11 C-PIB及单独11 C-PIB脑显像诊断AD的灵敏度均较正常E2组高,差异显著（χ^2=4.869,P=0.027;χ^2=3.636,P=0.047）;AD患者E2水平与SUVR及TNF-α表达水平均呈负相关关系（r=-0.363,P=0.001;r=-0.248,P=0.032）,而SUVR及TNF-α表达水平之间无明显相关性（r=0.161,P=0.168）;低E2水平AD患者组ApoE等位基因表达率高,差异显著（Z=-2.228,P=0.026）。结果表明,~（11）C-PIB和^18F-FDG联合显像对AD患者具有较高的诊断价值。
Bibliography:11-2566/TL
Alzheimer’s disease; estradiol; apolipoproteinE; tumor necrosis factor-α
The expressions of aplipoprotein E（ApoE）,tumor necrosis factor-α（TNF-α）in Alzheimer＇s disease（AD）patients with different levels of estrogen were investigated to evaluate the diagnosis of combined PET/CT imaging（11 C-PIB and 18 F-FDG）on AD.A total of 75 female AD patients were divided into low level of estradiol group（E2〈16.2 pmol/L,n=36）and normal level of estradiol group（16.2 pmol/L≤E265.7 pmol/L,n=39）according to their estradiol levels.All the patients underwent PET/CT imaging（11 C-PIB and 18 F-FDG）.The sensitivity of PET/CT imaging,the standard uptake value radio,the expression rates of subtype ApoE（ε2,ε3,ε4）,and the expression levels of TNF-αwere detected.The relationship between E2 and the expression rates of ApoE,the levels of TNF-αand SUVR were analyzed by Pearson analysis.In the low level of E2 group,the sensitivity of PET/CT for 11 C-PIB alone,11 C-PIB combined with 18 F-FDG was higher than in normal E2 group（χ^2=4.869,
ISSN:1000-7512
DOI:10.7538/tws.2017.youxian.035