The clinical effectiveness of one-dose vaccination with an HPV vaccine: A meta-analysis of 902,368 vaccinated women

• Published in: PloS one Vol. 19; no. 1; p. e0290808
• Main Authors: Setiawan, Didik, Nurulita, Nunuk Aries, Khoirunnisa, Sudewi Mukaromah, Postma, Maarten J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.01.2024; Public Library of Science (PLoS)
• Subjects: Bias; Budgets; Carcinogens; Cervical cancer; Clinical outcomes; Dosage; Effectiveness; Female; Health aspects; Human papillomavirus; Human papillomavirus 16; Humans; Immunization; Immunogenicity; Infection; Infections; Intervention; Medical research; Medical screening; Medicine, Experimental; Meta-analysis; Papillomavirus Vaccines; Prevention; Systematic review; Treatment Outcome; Vaccination; Vaccines; Women; Indonesia; India; Costa Rica
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0290808

The comprehensive effectiveness of the HPV vaccine has been widely acknowledged. However, challenges such as dosing adherence and limited budgets have led to delays in HPV vaccination implementation in many countries. A potential solution to these issues could lie in a one-dose vaccination with an HPV vaccine, as indicated by promising outcomes in multiple studies. In this systematic review and meta-analysis, we examine the comparative effectiveness of the one-dose vaccination with an HPV vaccine against two- and three-dose regimens. Our investigation focuses on clinical efficacy, encompassing the prevention of HPV16, HPV18, and hrHPV infections, HSIL or ASC-H incidence, and CIN2/3 incidence. Our analysis suggests that a single-dose HPV vaccine may offer effectiveness on par with two- or three-dose schedules. This conclusion is drawn from its capacity to confer immunogenic protection for at least 8 years of follow-up, coupled with its ability to mitigate infections and pre-cancerous occurrences. While our findings underscore the potential of the one-dose vaccination with an HPV vaccine, further research and prolonged study durations are necessary to establish robust evidence supporting this recommendation. As such, continued investigation will be critical for informing vaccination strategies.