Synthesis and Antiarrhythmic Activity of 2, 2-Dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-diones
A novel series of 2, 2-dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-diones was synthesized and evaluated for antiarrhythmic activity in chloroform- or/and aconitine-induced ventricular arrhythmia in mice. Among these compounds, (-)-6-chloro-2,...
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Published in | Chemical & pharmaceutical bulletin Vol. 40; no. 7; pp. 1823 - 1827 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
TOKYO
The Pharmaceutical Society of Japan
01.07.1992
Pharmaceutical Soc Japan Maruzen Japan Science and Technology Agency |
Subjects | |
Online Access | Get full text |
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Summary: | A novel series of 2, 2-dialkyl-1'-(N-substituted aminoalkyl)-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-diones was synthesized and evaluated for antiarrhythmic activity in chloroform- or/and aconitine-induced ventricular arrhythmia in mice. Among these compounds, (-)-6-chloro-2, 2-dimethyl-1'-[3-(4-hydroxypiperidino)propyl]-spiro-[chroman-4, 4'-imidazolidine]-2', 5'-dione was found to be more effective than reference agents and was selected for further development. |
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ISSN: | 0009-2363 1347-5223 |
DOI: | 10.1248/cpb.40.1823 |