Dual-color photoacoustic lymph node imaging using nanoformulated naphthalocyanines

Abstract Demarking lymph node networks is important for cancer staging in clinical practice. Here, we demonstrate in vivo dual-color photoacoustic lymphangiography using all-organic nanoformulated naphthalocyanines (referred to as nanonaps). Nanonap frozen micelles were self-assembled from two diffe...

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Bibliographic Details
Published inBiomaterials Vol. 73; pp. 142 - 148
Main Authors Lee, Changho, Kim, Jeesu, Zhang, Yumiao, Jeon, Mansik, Liu, Chengbo, Song, Liang, Lovell, Jonathan F, Kim, Chulhong
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.12.2015
Subjects
Acoustics
Advanced Basic Science
Animals
Biocompatibility
Biomedical materials
Breast Neoplasms - diagnosis
Breast Neoplasms - pathology
Carbocyanines - chemistry
Cell Movement
Chickens
Color
Dentistry
Female
Humans
Imaging
In vivo testing
In vivo tests
Lymph
Lymph Nodes - pathology
Mice
Mice, Inbred BALB C
Micelles
Nanoparticles - chemistry
Nanostructure
Nanotechnology - methods
Naphthalocyanines
Neoplasm Metastasis
Neoplasm Staging - methods
Optics and Photonics
Optoacoustic
Organic nanoparticles
Photoacoustic imaging
Rats
Rats, Sprague-Dawley
Sentinel Lymph Node Biopsy
Sentinel lymph node mapping
Spectrophotometry - methods
Surgical implants
Optoacoustic
Sentinel lymph node mapping
Photoacoustic imaging
Organic nanoparticles
Naphthalocyanines
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Summary:Abstract Demarking lymph node networks is important for cancer staging in clinical practice. Here, we demonstrate in vivo dual-color photoacoustic lymphangiography using all-organic nanoformulated naphthalocyanines (referred to as nanonaps). Nanonap frozen micelles were self-assembled from two different naphthalocyanine dyes with near-infrared absorption at 707 nm or 860 nm. These allowed for noninvasive, nonionizing, high resolution photoacoustic identification of separate lymphatic drainage systems in vivo . With both types of nanonaps, rat lymph nodes buried deeply below an exogenously-placed 10 mm thick layer of chicken breast were clearly visualized in vivo . These results show the potential of multispectral photoacoustic imaging with nanonaps for detailed mapping of lymphatic drainage systems.
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ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2015.09.023