Isolation of a new metabolite from biotransformation of daidzein by Aspergillus oryzae

• Published in: Bioscience, biotechnology, and biochemistry Vol. 73; no. 8; pp. 1877 - 1879
• Main Authors: Chen, Y.C.(Shizuoka Univ. (Japan)), Sugiyama, Y, Hirota, A
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01.08.2009; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: ALIMENT FERMENTE; ALIMENTOS FERMENTADOS; ANTIOXIDANTES; ANTIOXIDANTS; ANTIOXYDANT; ASPERGILLUS ORYZAE; Aspergillus oryzae - chemistry; Aspergillus oryzae - metabolism; Bioconversions. Hemisynthesis; Biological and medical sciences; Biotechnology; biotransformation; Biphenyl Compounds - chemistry; DAIDZEIN; DAIDZEINE; DAIDZEINO; FERMENTED FOODS; FLAVONOIDE; FLAVONOIDES; FLAVONOIDS; Free Radical Scavengers - chemistry; Free Radical Scavengers - isolation & purification; Free Radical Scavengers - metabolism; FREE RADICALS; Fundamental and applied biological sciences. Psychology; Isoflavones - chemistry; Isoflavones - isolation & purification; Isoflavones - metabolism; Magnetic Resonance Spectroscopy; METABOLITE; METABOLITES; METABOLITOS; Methods. Procedures. Technologies; Picrates - chemistry; RADICAL LIBRE; RADICALES LIBRES; Fungi; daidzein; Aspergillus oryzae; Metabolite; Biotransformation; Isolation; Fungi Imperfecti
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.90168

Two compounds were isolated from biotransformation of daidzein, a soybean isoflavone, by Aspergillus oryzae. One was 6,7,8,4′-tetrahydroxyisoflavone, an A-ring dihydroxylated daidzein, and the other was a novel compound which had the cleaved B-ring of daidzein. The former was perhaps derived from 8-hydroxydaidzein and/or 6-hydroxydaidzein, and had high DPPH radical-scavenging activity.