Immunological Consequences of Apoptotic Cell Phagocytosis

Cells undergo apoptosis in development, tissue homeostasis, and disease and are subsequently cleared by professional and nonprofessional phagocytes. There is now overwhelming evidence that phagocyte function is profoundly altered following apoptotic cell uptake, with consequences for the ensuing inn...

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Bibliographic Details
Published inThe American journal of pathology Vol. 171; no. 1; pp. 2 - 8
Main Authors Erwig, Lars-Peter, Henson, Peter M
Format Journal Article
LanguageEnglish
Published Bethesda, MD Elsevier Inc 01.07.2007
ASIP
American Society for Investigative Pathology
Subjects
Apoptosis
Autoimmunity
Biological and medical sciences
Biological s
Humans
Immunity, Active
Immunity, Innate
Inflammation - immunology
Investigative techniques, diagnostic techniques (general aspects)
Lymphocyte Activation
Macrophages - immunology
Medical sciences
Pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Phagocytosis
T-Lymphocytes - immunology
Anatomic pathology
Cell
Phagocytosis
Apoptosis
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Summary:Cells undergo apoptosis in development, tissue homeostasis, and disease and are subsequently cleared by professional and nonprofessional phagocytes. There is now overwhelming evidence that phagocyte function is profoundly altered following apoptotic cell uptake, with consequences for the ensuing innate and adaptive immune response. Pathogens and tumors exploit the changes in macrophage function following apoptotic cell uptake. Here, we will outline the consequences of apoptotic cell phagocytosis and illustrate how apoptotic cells could be used to manipulate the immune response for therapeutic gain.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0002-9440
1525-2191
DOI:10.2353/ajpath.2007.070135