aMMP-8 Point-of-Care Test (POCT) Identifies Reliably Periodontitis in Patients with Type 2 Diabetes as well as Monitors Treatment Response

• Published in: Diagnostics (Basel) Vol. 13; no. 13; p. 2224
• Main Authors: Heikkinen, Anna Maria, Sokka, Taru Tuulia, Torppa-Saarinen, Eeva, Pimiä, Elina, Jokinen, Minna, Maijala, Minna, Rantala, Iina, Tervahartiala, Taina, Sorsa, Timo, Kauppila, Timo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.06.2023; MDPI
• Subjects: aMMP-8; Body mass index; Care and treatment; Clinics; Communication; Cytokines; Diabetes; Diabetes therapy; Hyperglycemia; Inflammation; Medical research; Medicine, Experimental; Oral hygiene; Patients; Periodontitis; point-of-care test; Primary care; Type 2 diabetes; Finland; aMMP-8; diabetes; point-of-care test; periodontitis
• ISSN: 2075-4418; 2075-4418
• DOI: 10.3390/diagnostics13132224

The link between diabetes and periodontitis is bi-directional: high glucose levels increase the risk of periodontitis and elevated oral fluid aMMP-8 as well as diabetic development while untreated periodontitis worsens glycaemic control. Type-2 patients (N = 161) underwent an aMMP-8 Point-of-Care Test (POCT) at diabetes clinics. If the test was positive, the patient was sent to an oral health care clinic and oral health examination, health-promoting as well as necessary treatment procedures were carried out. Only 41 patients underwent full clinical evaluations. At the end of the treatment, an aMMP-8 POCT (B) was performed and if the test was positive, the treatment was continued and a new test (C) was performed, aiming for test negativity. The glycated haemoglobin (GHbA1c) test was performed approximately 6 months from the original appointment. GHbA1c concentrations did not decrease during the follow-up. The concentrations of aMMP-8 assessed by POCT, and clinical parameters decreased. Changes in GHbA1c and aMMP-8 levels assessed by POCT during the treatment correlated positively with each other ( < 0.01). aMMP-8 POCT proved its reliability, and that its use is beneficial in the diabetes clinic, it enables identifying patients with periodontal findings reliably and guides them directly to an oral health clinic.