Rise of the Pigs: Utilization of the Porcine Model to Study Musculoskeletal Biomechanics and Tissue Engineering During Skeletal Growth

Large animal models play an essential role in the study of tissue engineering and regenerative medicine (TERM), as well as biomechanics. The porcine model has been increasingly used to study the musculoskeletal system, including specific joints, such as the knee and temporomandibular joints, and tis...

Full description

Saved in:
Bibliographic Details
Published inTissue engineering. Part C, Methods Vol. 23; no. 11; pp. 763 - 780
Main Authors Cone, Stephanie G., Warren, Paul B., Fisher, Matthew B.
Format Journal Article
LanguageEnglish
Published United States Mary Ann Liebert, Inc 01.11.2017
Subjects
Animal models
Animals
Biomechanical Phenomena
Biomechanics
Bone Development
Cartilage
Comparative studies
Hogs
Knee
Ligaments
Models, Animal
Musculoskeletal Physiological Phenomena
Musculoskeletal system
Regenerative Medicine
Rodents
Skeletal system
Skin & tissue grafts
Special Focus
Special Focus Articles
Studies
Sus scrofa
Swine
Tissue Engineering
North Carolina
United States > US
animal models
ligament and tendon
bone
skeletal muscle
cartilage
Online AccessGet full text

Cover

More Information
Summary:Large animal models play an essential role in the study of tissue engineering and regenerative medicine (TERM), as well as biomechanics. The porcine model has been increasingly used to study the musculoskeletal system, including specific joints, such as the knee and temporomandibular joints, and tissues, such as bone, cartilage, and ligaments. In particular, pigs have been utilized to evaluate the role of skeletal growth on the biomechanics and engineered replacements of these joints and tissues. In this review, we explore the publication history of the use of pig models in biomechanics and TERM discuss interspecies comparative studies, highlight studies on the effect of skeletal growth and other biological considerations in the porcine model, and present challenges and emerging opportunities for using this model to study functional TERM.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
This article is part of a special focus issue on Animal Models in Tissue Engineering. Part I.
ISSN:1937-3384
1937-3392
DOI:10.1089/ten.tec.2017.0227