A New Type D Retrovirus Isolated from Macaques with an Immunodeficiency Syndrome

• Published in: Science (American Association for the Advancement of Science) Vol. 223; no. 4636; pp. 602 - 605
• Main Authors: Daniel, Muthiah D., King, Norval W., Letvin, Norman L., Hunt, Ronald D., Sehgal, Prabhat K., Desrosiers, Ronald C.
• Format: Journal Article
• Language: English
• Published: Washington, DC The American Association for the Advancement of Science 10.02.1984; American Association for the Advancement of Science
• Subjects: AIDS (Disease); AIDS research; AIDS/HIV; Animals; B lymphocytes; Biological and medical sciences; Burkitt Lymphoma; Cell culture techniques; Cell Line; Cell lines; Diseases; DNA; Hepatocytes; Humans; Immunodeficiencies. Immunoglobulinopathies; Immunologic Deficiency Syndromes - microbiology; Immunologic diseases; Immunopathology; Laboratory primates; Lymphocytes; Macaca; Macaca cyclopis; Macaques; Medical sciences; Nucleic Acid Hybridization; Observations; Physiological immunosuppression; Primates as laboratory animals; Retroviridae; Retroviridae - genetics; Retroviridae - immunology; Retroviridae - isolation & purification; T lymphocytes; Viral research; Virus research; Viruses; Human; Immunopathology; Hematology; Virological exploration; Monkey; AIDS; Type D oncovirus; Characterization; Vertebrata; Mixed cell culture; Mammalia; Transmission electron microscopy; Animal; Morphology; T-Lymphocyte; Primates; Isolation; Lymphoblastoid cell; Lymphocyte
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.6695172

Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolated from two Macaca cyclopis with this syndrome. This virus is related to, but distinct from, Mason-Pfizer monkey virus, a type D retrovirus previously isolated from a mammary tumor of a rhesus monkey (Macaca mulatta).