The ABCs of artificial antigen presentation

Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity. Artificial antigen-presenting cells (AAPCs) and their cell-free substitutes are designed to stimulate the expansion and acquisition of optimal therapeutic features of T cells before therapeutic inf...

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Published inNature biotechnology Vol. 22; no. 4; pp. 403 - 410
Main Authors Kim, Jiyun V, Latouche, Jean-Baptiste, Rivière, Isabelle, Sadelain, Michel
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.04.2004
Nature
Nature Publishing Group
Subjects
Agriculture
Animals
Antigen Presentation
Antigen-presenting cells
Antigen-Presenting Cells - cytology
Antigens
Antigens - chemistry
Beads
Bioinformatics
Biological and medical sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Cancer Vaccines - chemistry
Cell therapy
Cell-Free System
Cell-mediated immunity
Dendritic cells
Dendritic Cells - cytology
Exosomes
Fibroblasts - metabolism
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Humans
Immunity
Immunotherapy - methods
Industrial applications and implications. Economical aspects
Insecta
Interleukin 15
Interleukin-15 - metabolism
Life Sciences
Liposomes - metabolism
Lymphocytes
Lymphocytes T
Magnetics
Mice
Miscellaneous
Models, Biological
New technology
review-article
T-Lymphocytes - metabolism
Tumors
Vaccines, Synthetic
Antigen presentation
Clinical trial
Immunotherapy
T-Lymphocyte
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Abstract Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity. Artificial antigen-presenting cells (AAPCs) and their cell-free substitutes are designed to stimulate the expansion and acquisition of optimal therapeutic features of T cells before therapeutic infusion, without the need for autologous antigen-presenting cells. Compelling recent advances include fibroblast AAPCs that process antigens, magnetic beads that are antigen specific, novel T-cell costimulatory combinations, the augmentation of therapeutic potency of adoptively transferred T lymphocytes by interleukin-15, and the safe use of dendritic cell-derived exosomes pulsed with tumor antigen. Whereas the safety and potency of the various systems warrant further preclinical and clinical studies, these emerging technologies are poised to have a major impact on adoptive T-cell therapy and the investigation of T cell–mediated immunity.
AbstractList Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity. Artificial antigen-presenting cells (AAPCs) and their cell-free substitutes are designed to stimulate the expansion and acquisition of optimal therapeutic features of T cells before therapeutic infusion, without the need for autologous antigen-presenting cells. Compelling recent advances include fibroblast AAPCs that process antigens, magnetic beads that are antigen specific, novel T-cell costimulatory combinations, the augmentation of therapeutic potency of adoptively transferred T lymphocytes by interleukin-15, and the safe use of dendritic cell-derived exosomes pulsed with tumor antigen. Whereas the safety and potency of the various systems warrant further preclinical and clinical studies, these emerging technologies are poised to have a major impact on adoptive T-cell therapy and the investigation of T cell–mediated immunity.
Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity. Artificial antigen-presenting cells (AAPCs) and their cell-free substitutes are designed to stimulate the expansion and acquisition of optimal therapeutic features of T cells before therapeutic infusion, without the need for autologous antigen-presenting cells. Compelling recent advances include fibroblast AAPCs that process antigens, magnetic beads that are antigen specific, novel T-cell costimulatory combinations, the augmentation of therapeutic potency of adoptively transferred T lymphocytes by interleukin-15, and the safe use of dendritic cell-derived exosomes pulsed with tumor antigen. Whereas the safety and potency of the various systems warrant further preclinical and clinical studies, these emerging technologies are poised to have a major impact on adoptive T-cell therapy and the investigation of T cell-mediated immunity.Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity. Artificial antigen-presenting cells (AAPCs) and their cell-free substitutes are designed to stimulate the expansion and acquisition of optimal therapeutic features of T cells before therapeutic infusion, without the need for autologous antigen-presenting cells. Compelling recent advances include fibroblast AAPCs that process antigens, magnetic beads that are antigen specific, novel T-cell costimulatory combinations, the augmentation of therapeutic potency of adoptively transferred T lymphocytes by interleukin-15, and the safe use of dendritic cell-derived exosomes pulsed with tumor antigen. Whereas the safety and potency of the various systems warrant further preclinical and clinical studies, these emerging technologies are poised to have a major impact on adoptive T-cell therapy and the investigation of T cell-mediated immunity.
Audience Academic
Author Latouche, Jean-Baptiste
Sadelain, Michel
Kim, Jiyun V
Rivière, Isabelle
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  organization: Department of Medicine and Immunology Program, Laboratory of Gene Transfer and Gene Expression, Gene Transfer and Somatic Cell Engineering Facility, Memorial Sloan-Kettering Cancer Center
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Issue 4
Keywords Antigen presentation
Clinical trial
Immunotherapy
T-Lymphocyte
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Snippet Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity. Artificial antigen-presenting cells (AAPCs) and their...
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SubjectTerms Agriculture
Animals
Antigen Presentation
Antigen-presenting cells
Antigen-Presenting Cells - cytology
Antigens
Antigens - chemistry
Beads
Bioinformatics
Biological and medical sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Cancer Vaccines - chemistry
Cell therapy
Cell-Free System
Cell-mediated immunity
Dendritic cells
Dendritic Cells - cytology
Exosomes
Fibroblasts - metabolism
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Humans
Immunity
Immunotherapy - methods
Industrial applications and implications. Economical aspects
Insecta
Interleukin 15
Interleukin-15 - metabolism
Life Sciences
Liposomes - metabolism
Lymphocytes
Lymphocytes T
Magnetics
Mice
Miscellaneous
Models, Biological
New technology
review-article
T-Lymphocytes - metabolism
Tumors
Vaccines, Synthetic
Title The ABCs of artificial antigen presentation
URI https://link.springer.com/article/10.1038/nbt955
https://www.ncbi.nlm.nih.gov/pubmed/15060556
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Volume 22
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