The ABCs of artificial antigen presentation

• Published in: Nature biotechnology Vol. 22; no. 4; pp. 403 - 410
• Main Authors: Kim, Jiyun V, Latouche, Jean-Baptiste, Rivière, Isabelle, Sadelain, Michel
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.04.2004; Nature; Nature Publishing Group
• Subjects: Agriculture; Animals; Antigen Presentation; Antigen-presenting cells; Antigen-Presenting Cells - cytology; Antigens; Antigens - chemistry; Beads; Bioinformatics; Biological and medical sciences; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Cancer Vaccines - chemistry; Cell therapy; Cell-Free System; Cell-mediated immunity; Dendritic cells; Dendritic Cells - cytology; Exosomes; Fibroblasts - metabolism; Fundamental and applied biological sciences. Psychology; Health. Pharmaceutical industry; Humans; Immunity; Immunotherapy - methods; Industrial applications and implications. Economical aspects; Insecta; Interleukin 15; Interleukin-15 - metabolism; Life Sciences; Liposomes - metabolism; Lymphocytes; Lymphocytes T; Magnetics; Mice; Miscellaneous; Models, Biological; New technology; review-article; T-Lymphocytes - metabolism; Tumors; Vaccines, Synthetic; Antigen presentation; Clinical trial; Immunotherapy; T-Lymphocyte
• ISSN: 1087-0156; 1546-1696
• DOI: 10.1038/nbt955

Artificial antigen presentation aims to accelerate the establishment of therapeutic cellular immunity. Artificial antigen-presenting cells (AAPCs) and their cell-free substitutes are designed to stimulate the expansion and acquisition of optimal therapeutic features of T cells before therapeutic infusion, without the need for autologous antigen-presenting cells. Compelling recent advances include fibroblast AAPCs that process antigens, magnetic beads that are antigen specific, novel T-cell costimulatory combinations, the augmentation of therapeutic potency of adoptively transferred T lymphocytes by interleukin-15, and the safe use of dendritic cell-derived exosomes pulsed with tumor antigen. Whereas the safety and potency of the various systems warrant further preclinical and clinical studies, these emerging technologies are poised to have a major impact on adoptive T-cell therapy and the investigation of T cell–mediated immunity.