Gene therapy approaches to ventricular tachyarrhythmias

Abstract Ventricular tachycardia arising from a healed myocardial infarction scar continues to be a significant cause of morbidity and mortality. Drug therapy has been inadequate to meet this challenge, and implantable devices are limited by expense and technical problems. We have proposed the use o...

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Published inJournal of electrocardiology Vol. 40; no. 6; pp. S187 - S191
Main Authors Donahue, J. Kevin, MD, Sasano, Tetsuo, MD, PhD, Kelemen, Kamilla, MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2007
Elsevier Science Ltd
Subjects
Animals
Arrhythmia
Cardiovascular
Disease Models, Animal
ERG1 Potassium Channel
Ether-A-Go-Go Potassium Channels - genetics
Ether-A-Go-Go Potassium Channels - therapeutic use
Gene therapy
Genetic Therapy - methods
Humans
Myocardial infarction
Potassium channel
Swine
Tachycardia, Ventricular - genetics
Tachycardia, Ventricular - therapy
Treatment Outcome
Ventricular tachycardia
Myocardial infarction
Ventricular tachycardia
Arrhythmia
Gene therapy
Potassium channel
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Summary:Abstract Ventricular tachycardia arising from a healed myocardial infarction scar continues to be a significant cause of morbidity and mortality. Drug therapy has been inadequate to meet this challenge, and implantable devices are limited by expense and technical problems. We have proposed the use of gene therapy for cardiac arrhythmias. In this review, we present a model of postinfarct ventricular tachycardia, a method for gene delivery to this area, and results of KCNH2 -G628S gene transfer to manipulate cellular refractory properties in the arrhythmia model.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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corresponding author email: kdonahue@metrohealth.org
current address: Johns Hopkins University School of Medicine Ross 844 720 N. Rutland Ave. Baltimore, MD 21205
ISSN:0022-0736
1532-8430
DOI:10.1016/j.jelectrocard.2007.05.036