Single breath-hold 3D measurement of left atrial volume using compressed sensing cardiovascular magnetic resonance and a non-model-based reconstruction approach

• Published in: Journal of cardiovascular magnetic resonance Vol. 17; no. 1; p. 47
• Main Authors: Vardoulis, Orestis, Monney, Pierre, Bermano, Amit, Vaxman, Amir, Gotsman, Craig, Schwitter, Janine, Stuber, Matthias, Stergiopulos, Nikolaos, Schwitter, Juerg
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.06.2015; BioMed Central
• Subjects: Aged, 80 and over; Algorithms; Analysis; Atrial Function, Left; Breath Holding; Cardiovascular diseases; Data Compression; Diagnosis; Female; Heart Atria - pathology; Heart Atria - physiopathology; Heart Diseases - diagnosis; Heart Diseases - pathology; Heart Diseases - physiopathology; Humans; Image Interpretation, Computer-Assisted - methods; Magnetic Resonance Imaging, Cine - instrumentation; Magnetic Resonance Imaging, Cine - methods; Male; Measurement; Medical research; Medicine, Experimental; Methods; Middle Aged; Models, Cardiovascular; Observer Variation; Phantoms, Imaging; Physiological aspects; Predictive Value of Tests; Reproducibility of Results; Technical Notes; Time Factors; Young Adult
• ISSN: 1097-6647; 1532-429X
• DOI: 10.1186/s12968-015-0147-8

Left atrial (LA) dilatation is associated with a large variety of cardiac diseases. Current cardiovascular magnetic resonance (CMR) strategies to measure LA volumes are based on multi-breath-hold multi-slice acquisitions, which are time-consuming and susceptible to misregistration. To develop a time-efficient single breath-hold 3D CMR acquisition and reconstruction method to precisely measure LA volumes and function. A highly accelerated compressed-sensing multi-slice cine sequence (CS-cineCMR) was combined with a non-model-based 3D reconstruction method to measure LA volumes with high temporal and spatial resolution during a single breath-hold. This approach was validated in LA phantoms of different shapes and applied in 3 patients. In addition, the influence of slice orientations on accuracy was evaluated in the LA phantoms for the new approach in comparison with a conventional model-based biplane area-length reconstruction. As a reference in patients, a self-navigated high-resolution whole-heart 3D dataset (3D-HR-CMR) was acquired during mid-diastole to yield accurate LA volumes. Phantom studies. LA volumes were accurately measured by CS-cineCMR with a mean difference of -4.73 ± 1.75 ml (-8.67 ± 3.54%, r2 = 0.94). For the new method the calculated volumes were not significantly different when different orientations of the CS-cineCMR slices were applied to cover the LA phantoms. Long-axis "aligned" vs "not aligned" with the phantom long-axis yielded similar differences vs the reference volume (-4.87 ± 1.73 ml vs. -4.45 ± 1.97 ml, p = 0.67) and short-axis "perpendicular" vs. "not-perpendicular" with the LA long-axis (-4.72 ± 1.66 ml vs. -4.75 ± 2.13 ml; p = 0.98). The conventional bi-plane area-length method was susceptible for slice orientations (p = 0.0085 for the interaction of "slice orientation" and "reconstruction technique", 2-way ANOVA for repeated measures). To use the 3D-HR-CMR as the reference for LA volumes in patients, it was validated in the LA phantoms (mean difference: -1.37 ± 1.35 ml, -2.38 ± 2.44%, r2 = 0.97). Patient study: The CS-cineCMR LA volumes of the mid-diastolic frame matched closely with the reference LA volume (measured by 3D-HR-CMR) with a difference of -2.66 ± 6.5 ml (3.0% underestimation; true LA volumes: 63 ml, 62 ml, and 395 ml). Finally, a high intra- and inter-observer agreement for maximal and minimal LA volume measurement is also shown. The proposed method combines a highly accelerated single-breathhold compressed-sensing multi-slice CMR technique with a non-model-based 3D reconstruction to accurately and reproducibly measure LA volumes and function.