Tracing cellular dynamics in tissue development, maintenance and disease

The coordination of cell proliferation and differentiation is central to the development and maintenance of tissues, while its dysregulation underlies the transition to diseased states. By combining lineage tracing with transcriptional profiling and marker-based assays, statistical methods are deliv...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 43; pp. 38 - 45
Main Authors Rulands, Steffen, Simons, Benjamin D
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2016
Subjects
Animals
Cell Differentiation - physiology
Cell Lineage
Cells - pathology
Disease
Humans
Internal Medicine
Organogenesis
Stem Cells - cytology
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Summary:The coordination of cell proliferation and differentiation is central to the development and maintenance of tissues, while its dysregulation underlies the transition to diseased states. By combining lineage tracing with transcriptional profiling and marker-based assays, statistical methods are delivering insights into the dynamics of stem cells and their developmental precursors. These studies have provided evidence for molecular heterogeneity and fate priming, and have revealed a role for stochasticity in stem cell fate, refocusing the search for regulatory mechanisms. At the same time, they present a quantitative platform to study the initiation and progression of disease. Here, we review how quantitative lineage tracing strategies are shaping our understanding of the cellular mechanisms of tissue development, maintenance and disease.
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ISSN:0955-0674
1879-0410
1879-0410
DOI:10.1016/j.ceb.2016.07.001