DNA as a Versatile Chemical Component for Catalysis, Encoding, and Stereocontrol

DNA (deoxyribonucleic acid) is the genetic material common to all of Earth's organisms. Our biological understanding of DNA is extensive and well-exploited. In recent years, chemists have begun to develop DNA for nonbiological applications in catalysis, encoding, and stereochemical control. Thi...

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Published inAngewandte Chemie (International ed.) Vol. 49; no. 40; pp. 7180 - 7201
Main Author Silverman, Scott K
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 24.09.2010
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Catalysis
directed evolution
DNA
DNA - chemistry
encoding
RNA, Catalytic
stereocontrol
Stereoisomerism
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Summary:DNA (deoxyribonucleic acid) is the genetic material common to all of Earth's organisms. Our biological understanding of DNA is extensive and well-exploited. In recent years, chemists have begun to develop DNA for nonbiological applications in catalysis, encoding, and stereochemical control. This Review summarizes key advances in these three exciting research areas, each of which takes advantage of a different subset of DNA's useful chemical properties.
Bibliography:http://dx.doi.org/10.1002/anie.200906345
Defense Threat Reduction Agency
Burroughs Wellcome Fund
ArticleID:ANIE200906345
The frontispiece shows three different chemical applications of DNA as a catalyst, as an encoding component, and as a chiral ligand for stereocontrol.
ACS Petroleum Research Fund
National Institutes of Health
istex:DF695884AC6DC9B038091BCBBAF80BF45110FB17
ark:/67375/WNG-Q79912PN-W
David and Lucile Packard Foundation
March of Dimes
University of Illinois
National Science Foundation
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200906345