Oseltamivir-resistant 2009–2010 pandemic influenza A (H1N1) in an immunocompromised patient

• Published in: Clinical microbiology and infection Vol. 16; no. 10; pp. 1576 - 1578
• Main Authors: Chan, P.A, Connell, N.T, Gabonay, A.M, Westley, B., Larkin, J.M, LaRosa, S.P, Chapin, K., Mermel, L.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier Ltd 01.10.2010; Blackwell Publishing Ltd; Wiley-Blackwell; Elsevier Limited
• Subjects: Adult; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Biological and medical sciences; Drug Resistance, Viral; Exo- alpha -sialidase; Female; H1N1; Hematologic Neoplasms - complications; Hematologic Neoplasms - drug therapy; Human viral diseases; Humans; immunocompromised; Immunocompromised Host; Immunocompromised hosts; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Influenza; Influenza A; Influenza A Virus, H1N1 Subtype - drug effects; Influenza A Virus, H1N1 Subtype - isolation & purification; Influenza, Human - virology; Malignancy; Medical sciences; Oseltamivir; Oseltamivir - pharmacology; Oseltamivir - therapeutic use; Pandemics; Pharmacology. Drug treatments; resistance; United States; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; United States; influenza A; immunocompromised; oseltamivir; H1N1; resistance; Human; Immunopathology; Neuraminidase inhibitor; Enzyme; Respiratory disease; H1N1 influenza; Enzyme inhibitor; Immune deficiency; Glycosylases; Infection; Resistance; Oseltamivir; Exo-α-sialidase; Glycosidases; Viral disease; Influenza A (H1N1); Hydrolases; Antiviral; Influenza A
• ISSN: 1198-743X; 1469-0691
• DOI: 10.1111/j.1469-0691.2010.03212.x

Although neuraminidase inhibitors are active against most 2009–2010 pandemic influenza A (H1N1) swine-origin strains, sporadic cases of oseltamivir resistance have been described. Since April 2009, 54 cases of oseltamivir-resistant H1N1 swine-origin have been reported in the USA (http://www.cdc.gov/flu/weekly/; accessed 1 February 2010). Approximately 1.4% of tested isolates are oseltamivir resistant. We report a patient with an underlying hematological malignancy who was hospitalized with influenza A (H1N1) swine-origin and whose strain developed oseltamivir resistance during therapy.