Peripheral expression of inflammatory markers in overweight female adolescents and eutrophic female adolescents with a high percentage of body fat

• Published in: Applied physiology, nutrition, and metabolism Vol. 35; no. 4; pp. 464 - 470
• Main Authors: Carvalho, Gisele Queiroz, Pereira, Patrícia Feliciano, Serrano, Hiara Miguel Stancioli, do Carmo Castro Franceschini, Sylvia, Oliveira de Paula, Sérgio, Priore, Silvia Eloiza, do Carmo Gouveia Peluzio, Maria
• Format: Journal Article
• Language: English
• Published: Ottawa Presses scientifiques du CNRC 01.08.2010; NRC Research Press; Canadian Science Publishing NRC Research Press
• Subjects: Adipose tissues; Adiposity; Adolescent; adolescentes; adolescents; Biological and medical sciences; Biomarkers - blood; Blood Glucose - analysis; Blood Pressure; Body fat; Body Weight; Brazil; Cardiovascular Diseases - etiology; Chronic diseases; Cross-Sectional Studies; Cytokines; Female; Females; Fundamental and applied biological sciences. Psychology; Gene expression; Genetic aspects; Humans; inflammation; Inflammation - blood; Inflammation - immunology; Inflammation - physiopathology; Inflammation Mediators - blood; Insulin Resistance; Interleukin-10 - blood; Interleukin-6 - blood; Interleukins; Lipids - blood; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - immunology; Metabolic Syndrome - physiopathology; metabolic syndrome X; Obesity; obésité; Overweight - blood; Overweight - immunology; Overweight - physiopathology; Physiological aspects; Risk Assessment; Risk Factors; syndrome métabolique X; Teenagers; TNF- α; Tumor Necrosis Factor-alpha - blood; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports; Waist Circumference; Brazil; Endocrinopathy; Human; Obesity; Adipose tissue; Nutrition disorder; Cytokine; Metabolic diseases; Cardiovascular disease; Inflammation; Metabolic syndrome; Overweight; Adolescent; Female; Nutritional status
• ISSN: 1715-5312; 1715-5320
• DOI: 10.1139/H10-033

The objective of this study was to evaluate the peripheral expression of inflammatory markers in adolescents with different nutritional status and its correlation with parameters of the metabolic syndrome. Seventy-two female postpubescent adolescents were divided into 3 groups: eutrophic (Co), eutrophic with a high body fat percentage (HBF), and overweight (OW). Data related to the parameters of the metabolic syndrome and the peripheral expression of tumour necrosis factor (TNF)- α, interleukin (IL)-6, and IL-10 were evaluated. Higher values of glycemia and insulin resistance were found in the HBF group than in the Co group. No differences related to the peripheral expression of the cytokines were found among the groups. In the HBF group, a positive correlation was observed between TNF- α and IL-6, IL-10 and the proinflammatory cytokines, and IL-6 and glycemia. In the OW group, a positive correlation was found between IL-6 and triglycerides. Adolescents with normal weight but body fat excess present a metabolic profile and body composition similar to those of overweight adolescents. This suggests that these adolescents have a risk of developing cardiovascular diseases similar to that of overweight adolescents. The positive correlation between IL-10 and TNF- α and IL-6 suggests an attempt to inhibit the production of these cytokines by IL-10.